Zobrazeno 1 - 10
of 84
pro vyhledávání: '"D. C. Rijken"'
Publikováno v:
Fibrinolysis. 8:9-15
Urokinase-type plasminogen activator (u-PA) occurs either in a single-chain form or in a two chain form (scu-PA or tcu-PA, respectively). The occurrence of the different forms of u-PA and the formation of u-PA-inhibitor complexes was studied in urine
Autor:
E M, De Wee, K, Klaij, H C J, Eikenboom, J G, Van Der Bom, K, Fijnvandraat, B A P, Laros-Van Gorkom, E P, Mauser-Bunschoten, K, Meijer, G, Goverde, P W G, Van Der Linden, D C, Rijken, F W G, Leebeek
Publikováno v:
Haemophilia : the official journal of the World Federation of Hemophilia. 18(3)
Patients with von Willebrand disease (VWD), the most common inherited bleeding disorder, display large variation in bleeding tendency, which is not completely related to VWF levels. The cause of variability in clinical expression is largely unknown.
Publikováno v:
Thrombosis and Haemostasis. 70:867-872
SummaryIn order to define the possible effects of heparin on the fibrinolytic system under physiological conditions, we studied the interactions of this drug with plasminogen and its activators at various ionic strengths. As reported in recent litera
Publikováno v:
Journal of Biological Chemistry. 267:1589-1595
The plasma clearance and the interaction of high (HMW) and low (LMW) molecular weight single-chain urokinase-type plasminogen activator (scu-PA) with rat liver cells was determined. 125I-Labeled HMW- and LMW-scu-PA were rapidly cleared from plasma wi
Autor:
D. C. Rijken, G.A.W. de Munk
Publikováno v:
Fibrinolysis. 4:1-9
Publikováno v:
British journal of haematology. 124(5)
Thrombin activatable fibrinolysis inhibitor (TAFI) antigen levels exhibit a large interindividual variability in which genetic control seems to play a major role. However, recent reports have questioned the association between TAFI concentration and
Autor:
D C, Rijken, M E, van der Kaaden, E, Groeneveld, M M, Barrett-Bergshoeff, Th J C, van Berkel, J, Kuiper
Publikováno v:
Thrombosis and haemostasis. 88(1)
In order to study the role of the asialoglycoprotein receptor (ASGPr) in the rapid plasma clearance of urokinase-type plasminogen activator (u-PA), a microtiter plate binding assay was developed using ASGPr purified from rat liver extracts. Urinary t
Publikováno v:
European journal of biochemistry. 268(21)
Single-chain urokinase-type plasminogen activator (scu-PA) can be cleaved by thrombin into a virtually inactive form called thrombin-cleaved two-chain urokinase-type plasminogen activator (tcu-PA/T), a process accelerated by thrombomodulin, which con
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology, 6, 21, 943-948
We present the first steps in the elaboration of an approach of extracellular matrix-targeted local drug delivery (ECM-LDD), designed to provide a high concentration, ubiquitous distribution, and long-term retention of a drug within the vessel wall a
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Publikováno v:
Thrombosis research. 100(4)
High-frequency ultrasound has been shown to accelerate enzymatic fibrinolysis. One of the supposed mechanisms of this effect is the enhancement of mass transport by acoustic streaming, i.e., ultrasound-induced macroscopic flow around the clot. In thi