Výsledky vyhledávání - "D. C. Mikulecky"

Autor: D. C. Mikulecky

Publikováno v: Mathematical and Computer Modelling. 19(6-8):99-118

The network concept of n-ports is reviewed from the perspective of its natural correspondence to the nonequilibrium thermodynamic approach to energy conversion in coupled systems. New insights into the basic, fundamental structure of thermodynamics a

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Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates

Autor: I D Goldman, T J Rape, D F Trent, D C Mikulecky, R L Seither

Publikováno v: Journal of Biological Chemistry. 266:4112-4118

An important unresolved issue in antifolate pharmacology is the basis for the observation that the major portion of cellular tetrahydrofolate cofactors is preserved after dihydrofolate reductase activity is abolished by antifolates despite the fact t

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https://doi.org/10.1016/s0021-9258(20)64293-4

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SPICE2 network thermodynamic simulation of antifolate effects on purine and pyrimidine biosynthesis: Exploring the role of tetrahydrofolate cofactor depletion versus dihydrofolate feedback inhibition

Autor: I D Goldman, R L Seither, D. Hearne, D C Mikulecky, D F Trent

Publikováno v: Computers & Mathematics with Applications. 20:87-101

Utilizing the network thermodynamic approach, it is possible to simulate large, nonlinear dynamic systems on SPICE2. For this purpose SPICE2 can become a general systems simulator in spite of the fact that it was originally designed for simulating in

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https://doi.org/10.1016/0898-1221(90)90318-e

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Determining the transient kinetic behavior of complex multi-enzyme systems by use of network thermodynamics

Autor: D C, Mikulecky, M, Thellier

Publikováno v: Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie. 316(12)

As an example of the application of network thermodynamics to the treatment of complicated enzymatic systems, we have studied the transient kinetic behavior of a sequence of five enzymatic reactions, four with Michaelis-Menten kinetics and the final

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https://pubmed.ncbi.nlm.nih.gov/8087618

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Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates. Influence of degree of dihydrofolate reductase inhibition

Autor: R L, Seither, D F, Trent, D C, Mikulecky, T J, Rape, I D, Goldman

Publikováno v: The Journal of biological chemistry. 266(7)

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https://pubmed.ncbi.nlm.nih.gov/1825652

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When is a mechanism not a mechanism? The network thermodynamic approach to complex systems

Autor: D. C. Mikulecky

Publikováno v: Mathematical and Computer Modelling. 11:464-468

Rosen (1985) has made a distinction between two classes of objects, ''mechanisms'' and ''complex systems''. One central distinguishing feature is the applicability of the Newtonian paradigm. Mechanisms are describable with this formalism, while compl

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Network thermodynamic modeling of hormone regulation of active Na+ transport in cultured renal epithelium (A6)

Autor: M. L. Fidelman, D. C. Mikulecky

Publikováno v: American Journal of Physiology-Cell Physiology. 250:C978-C991

A network thermodynamic model was developed to describe steady-state ion flows (Na+,K+, and Cl-) and related electrical events in a cultured renal epithelium (A6) derived from toad kidney. Three hypotheses for explaining the steady-state increases in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b6843e90ea8f61dd26ddf6127152f6
https://doi.org/10.1152/ajpcell.1986.250.6.c978

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Folate-Pool Interconversions and Inhibition of Biosynthetic Processes after Exposure of L1210 Leukemia Cells to Antifolates

Autor: D C Mikulecky, D F Trent, I D Goldman, T J Rape, R L Seither

Publikováno v: Journal of Biological Chemistry. 264:17016-17023

Folate analogs that inhibit dihydrofolate reductase result in only partial interconversion of tetrahydrofolate cofactors to dihydrofolate with preservation of the major portion of reduced cellular folate cofactors in L1210 leukemia cells. One possibl

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https://doi.org/10.1016/s0021-9258(18)71452-x

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A network thermodynamic model of salt and water flow across the kidney proximal tubule

Autor: D. C. Mikulecky, S. R. Thomas

Publikováno v: American Journal of Physiology-Renal Physiology. 235:F638-F648

This network thermodynamic model of kidney proximal tubule epithelium treats coupled salt and water flow across each component membrane of the epithelium. We investigate the effects of various relative internal parameter values on the concentration o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::badbdb965245a0a55f5d91d752e6bb42
https://doi.org/10.1152/ajprenal.1978.235.6.f638

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