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pro vyhledávání: '"D. C. J. Jaikaran"'
Publikováno v:
Biochemistry. 36(45)
Alamethicin channels are prototypical helix bundles that may serve as tractable models for more complex protein ion channels. Solid-phase peptide synthesis of alamethicin analogues using FMOC-amino acid fluorides followed by chemical dimerization of
Publikováno v:
Biochemistry. 36(6)
We have synthesized a novel thiol reagent, 2-[(methylsulfonyl)thio]ethyl [N-(N,N-dimethylamino)ethyl]carbamate (MTSAC), that contains a carbamate functional group as well as a (positively charged) terminal amino group. The carbamate C-N bond isomeriz
Autor:
Karin A. Crowhurst, D. C. J. Jaikaran, P. C. Biggin, Mark S.P. Sansom, G. A. Woolley, Linda Lien, J. Breed, A. Schultz
Publikováno v:
Scopus-Elsevier
Covalent dimers of alamethicin form conducting structures with gating properties that permit measurement of current-voltage (I-V) relationships during the lifetime of a single channel. These I-V curves demonstrate that the alamethicin channel is a re