Zobrazeno 1 - 10 of 105 pro vyhledávání: '"D. C. Cooper"'
1
Protein arginine deiminase 4 inhibition is sufficient for the amelioration of collagen-induced arthritis
Autor: Nirmal K. Banda, Huw D. Lewis, Paul P. Tak, Simon Taylor, William H. Robinson, Dave Lugo, V M Holers, Gaurav Mehta, Rab K. Prinjha, D C Cooper, Piyanka E Chandra, Kristen N. Cordova, Van C. Willis
Publikováno v: Clinical and experimental immunology. 188(2)
Summary Citrullination of joint proteins by the protein arginine deiminase (PAD) family of enzymes is recognized increasingly as a key process in the pathogenesis of rheumatoid arthritis. This present study was undertaken to explore the efficacy of a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f75c3374cef7d557b2f0bc32d36ccc0c
https://pubmed.ncbi.nlm.nih.gov/28128853
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2
Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model
Autor: D C Cooper, M L Bergquist, Pat Wheelan, K I MacKenzie, Sean Ross, Mir Hashim, J D Becherer, Don L. Anderson, B Z Desai, Daniel G. Lang, Xiaozhou Yao, Maggie S. McIntyre
Publikováno v: British Journal of Pharmacology. 154:1446-1456
Background and purpose: Drug-induced prolongation of the QT interval can lead to torsade de pointes, a life-threatening ventricular arrhythmia. Finding appropriate assays from among the plethora of options available to predict reliably this serious a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e2b9101dff4148be1f380d000b84782
https://doi.org/10.1038/bjp.2008.267
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3
On the occurrence of an unusual form of monazite in panned stream sediments in Wales
Autor: D. C. Cooper, T. K. Smith, I. R. Basham
Publikováno v: Geological Journal. 18:121-127
An unusual nodular form of monazite has been found to account for abnormally high levels of cerium in panned heavy mineral concentrates from stream sediments in several areas in Wales and pan of Exmoor. Textural features indicate a pre-metamorphic, d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::050795184f8868a9c8ac53d27eae518b
https://doi.org/10.1002/gj.3350180204
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6
The ammonium content of granites in the English Lake District
Autor: D. C. Cooper, A. D. Bradley
Publikováno v: Geological Magazine. 127:579-586
Granitic rocks from all the exposed components of the Lake District batholith have been analysed for ammonium to look for evidence of an ammonium-rich sedimentaryprotolith. The results indicate that the ammonium content of Lake District granites is r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25f26513001c866317f57774d8fdbd94
https://doi.org/10.1017/s0016756800015466
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7
Dopamine D3 receptor mutant and wild-type mice exhibit identical responses to putative D3 receptor-selective agonists and antagonists
Autor: M, Xu, T E, Koeltzow, D C, Cooper, S, Tonegawa, F J, White
Publikováno v: Synapse (New York, N.Y.). 31(3)
Previous studies using a variety of drugs with different affinities for the dopamine (DA) D3 receptor suggested that this receptor is involved in regulating motor activity and hypothermia. However, the in vivo selectivity of many of these compounds h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22c0437d81fc78b2d1f07e4dbe9562f8
https://pubmed.ncbi.nlm.nih.gov/10029239
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8
Selection for white kernel color in the progeny of red/white wheat crosses
Autor: D. C. Cooper, Mark E. Sorrells
Publikováno v: Euphytica. 33:227-232
Data are presented which support early generation selection for white kernel color in the progeny of red/white kernel wheat crosses which are segregating at 12 or more loci for yield (or any other trait of interest). The optimum generation for select
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81685e5481a00bf9de00c245042c9ece
https://doi.org/10.1007/bf00022770
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9
The Crummock Water aureole: a zone of metasomatism and source of ore metals in the English Lake District
Autor: P. M. Allen, N. J. Fortey, Anthony H. Cooper, B. C. Webb, C. C. Rundle, M. K. Lee, D. C. Cooper
Publikováno v: Journal of the Geological Society. 145:523-540
The Crummock Water aureole, an ENE-trending elongate zone of bleached and recrystallized Skiddaw Group rocks, 24 km in length and up to 3 km wide, is a zone in which pervasive metasomatism has modified the composition of the dominantly siltstone and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da8325858b60810b7bec1ca8cdd876f7
https://doi.org/10.1144/gsjgs.145.4.0523
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10
The composition and distribution of nodular monazite in the Lower Palaeozoic rocks of Great Britain
Autor: D. Read, John M. McArthur, D. C. Cooper
Publikováno v: Mineralogical Magazine. 51:271-280
Millimetric, ellipsoidal monazite nodules found within Lower Palaeozoic sedimentary rocks in Wales, south-west England and Brittany are characterised by a pronounced zonation of light and heavy REE, an inclusion fabric of low-grade metamorphic minera
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::793117180a3a86da28f48741b9b93ca5
https://doi.org/10.1180/minmag.1987.051.360.09
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