Zobrazeno 1 - 10
of 18
pro vyhledávání: '"D. C. Billington"'
Autor:
E, Lattmann, J, Sattayasai, P, Lattmann, D C, Billington, C H, Schwalbe, J, Boonprakob, W, Airarat, H, Singh, M, Offel, A, Staaf
Publikováno v:
Drug discoveriestherapeutics. 1(1)
Various 1,4-benzodiazepines were synthesized around a Diazepam, Oxazepam and the n-propyl-1,4-benzodiazepine template. SAR studies of CCK(2) binding affinity were performed and selected examples of each series were tested in vivo in mice. In addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66de868444f92dc3f6b601987f0130c4
https://pubmed.ncbi.nlm.nih.gov/22504363
https://pubmed.ncbi.nlm.nih.gov/22504363
Autor:
I. M. Mawer, D. C. Billington, R. Baker, Steven D. Young, S. J. De Solms, Joseph P. Vacca, J. J. Kulagowski, Joel R. Huff
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::730ab38d9d5119ce22c11d4af293a894
https://doi.org/10.1002/chin.199152347
https://doi.org/10.1002/chin.199152347
Publikováno v:
Drug design and discovery. 17(3)
The SAR of Asperlicin analogues is reported, leading to bioactive 1,4-benzodiazepine-2-ones, which were prepared in a 3 step reaction sequence. The Asperlicin substructure was built up using Tryptophan and readily available 2-amino-acetophenones. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1f96c412afb8887f460701dec1b15ea
https://pubmed.ncbi.nlm.nih.gov/11469752
https://pubmed.ncbi.nlm.nih.gov/11469752
Publikováno v:
Drug design and discovery. 16(3)
A three dimensional combinatorial library of 3-halogen-4-amino-5-alkoxy-2(5H)-furanones has been prepared by applying solution phase combinatorial chemistry techniques. The substituents in the 3-4-5-positions of a butenolide scaffold were varied inde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ad8d04d7de05ae248ca7bd10ce36cf5
https://pubmed.ncbi.nlm.nih.gov/10624570
https://pubmed.ncbi.nlm.nih.gov/10624570
Publikováno v:
Drug design and discovery. 16(3)
Starting from furfural, 5-hydroxy-3,4-dihalo-2(5H)-furanones and 5-hydroxy-4 chloro-2(5H)-furanone were converted into 3 sublibraries of halogenated 5-alkoxy-2(5H)-furanones. The reactivity of 24 halogenated 5-alkoxy2(5H)-furanones was chemically eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e6e1f085186a3f8a7b09b5839446de5
https://pubmed.ncbi.nlm.nih.gov/10624569
https://pubmed.ncbi.nlm.nih.gov/10624569
Autor:
S, Augy-Dorey, D C, Billington, J A, Camara, S D, Gero, I, Sagnard, B, Quiclet-Sire, D, Ghezzi
Publikováno v:
Drug design and discovery. 16(1)
We have synthesised a number of analogues of lipid X, a precursor in the biosynthesis of LPS, some of which exhibit marked antagonism of LPS induced TNF production in vivo. These compounds provide new non-polar leads in the search for a therapy for e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7cbbfb4d91e38e8c9e7b7fc1242fb524
https://pubmed.ncbi.nlm.nih.gov/10466055
https://pubmed.ncbi.nlm.nih.gov/10466055
Autor:
D C, Billington
Publikováno v:
Drug design and discovery. 8(1)
To summarise the key points: The ability to mount an angiogenic response is probably present in all tissues, and stimulation of endothelial cells by any one of a wide variety of factors initiates a cascade of events leading to angiogenesis. In most t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dec8434312768b14a734b82a089146b2
https://pubmed.ncbi.nlm.nih.gov/1725722
https://pubmed.ncbi.nlm.nih.gov/1725722
Autor:
Michael Offel, Pornthip Lattmann, Harjit Singh, D. C. Billington, Yodchai Bunprakob, Jintana Sattayasai
Publikováno v:
Archiv der Pharmazie; Apr2006, Vol. 339 Issue 4, p163-173, 11p
Autor:
R. Baker, S Aspley, Robert J. Barnaby, R G Jackson, N S Gee, C I Ragan, K J Watling, D C Billington, Paul D. Leeson, G G Reid
Publikováno v:
Biochemical Journal. 249:143-148
1. Hydrolysis of both enantiomers of inositol 1-phosphate and both enantiomers of inositol 4-phosphate to inositol is inhibited by LiCl in liver and brain. 2. The phosphatase activity is predominantly soluble. 3. Inositol 1,4-bisphosphate is also hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7520d28f49ed4db0bd9a04194149be
https://doi.org/10.1042/bj2490143
https://doi.org/10.1042/bj2490143