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Elektronická kniha

Autor: D. Brusick

The field of genetic toxicology has gone through remarkable development in the seven years since the appearance of the first edition of Principles of Genetic Toxicology. One branch of toxicology research, chemical mutagenesis, has been elucidated and

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Correlation of carcinogenic potency with mouse-skin 32P-postlabeling and muta-Rmouse lac Z− mutation data for DMBA and its K-region sulphur isostere: comparison with activities observed in standard genotoxicity assays

Autor: N.J. Jones, Helen Tinwell, S. Curti, Herbert S. Rosenkranz, James M. Parry, D. Brusick, D. Paton, R.D. Callander, D. Gilman, John Ashby, B.C. Myhr, S. Nesnow

Publikováno v: Mutation Research/Environmental Mutagenesis and Related Subjects. 292:25-40

The genotoxicities in vitro and in vivo of the mouse-skin carcinogen 7,12-dimethylbenz[a]anthracene (DMBA) have been compared with those of its weakly carcinogenic 4,5-sulphur analogue, 6,11-dimethylbenzo[b]naphtho-[2,3-d]thiophene (S-DMBA). The only

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6e632442f0491a9f604d2bb40bddc5
https://doi.org/10.1016/0165-1161(93)90005-k

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Report of the Validation and Technology Transfer committee of the Johns Hopkins Center for Alternatives to Animal Testing Framework for validation and implementation ofin vitrotoxicity tests

Autor: Kevin J. Renskers, S.D. Gettings, Michael S. Dickens, Robert L. Lipnick, Richard N. Hill, N.L. Wilcox, June A. Bradlaw, Oliver P. Flint, John M. Frazier, Sidney Green, D. Brusick, R. D. Curren, Alan M. Goldberg, R. A. Scala, Bellina Veronesi

Publikováno v: Xenobiotica. 23:563-572

The development and application of in vitro alternatives designed to reduce or replace the use of animals, or to lessen the distress and discomfort of laboratory animals, is a rapidly developing trend in toxicology. However, at present there is no fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00da9d8874db08d87dbf4f337ad0e80
https://doi.org/10.3109/00498259309059395

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Report and Recommendations of the CAAT/ERGATT Workshop on the Validation of Toxicity Test Procedures

Autor: Michael Balls, Herbert S. Rosenkranz, Horst Spielmann, Marcel Roberfroid, Bas J. Blaauboer, John M. Frazier, Christoph A. Reinhardt, B. P. Schmid, Al. Stammati, D. Lamb, Erik Walum, M. Pemberton, D. Brusick

Publikováno v: Alternatives to Laboratory Animals. 18:313-337

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69bee7baecd8b005fa9b2cdaabac3b73
https://doi.org/10.1177/026119299001800131.1

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Genotoxicity of radiofrequency radiation. DNA/Genetox Expert Panel

Autor: D, Brusick, R, Albertini, D, McRee, D, Peterson, G, Williams, P, Hanawalt, J, Preston

Publikováno v: Environmental and molecular mutagenesis. 32(1)

During the past several years, concerns have been raised regarding the potential adverse effects of exposures to nonionizing radiation, particularly in the extremely low frequency (ELF) range (50 to 60 MHz) and radiofrequency radiation (RFR) with fre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c3ec554de4c8d258063924bc1f0e3716
https://pubmed.ncbi.nlm.nih.gov/9707093

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International Commission for Protection Against Environmental Mutagens and Carcinogens. Genetic risk extrapolation from animal data to human disease. A Taskgroup Report. No. 00105

Autor: J, Favor, D, Layton, G, Sega, J, Wassom, J, Burkhart, G, Douglas, K, Dearfield, D, Brusick

Publikováno v: Mutation research. 330(1-2)

This report describes a model for producing quantitative genetic risk assessments for human populations. The model is patterned after current methods used in cancer risk analysis. The risk to humans is expressed as the number of additional dominant g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::218cc9a42cd7e184a9c3cdb9083345c6
https://pubmed.ncbi.nlm.nih.gov/7623868

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Applications for transgenic animals in toxicology

Autor: D, Brusick

Publikováno v: Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement. 17

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a57dfabe3f9bbb198ca501536d2c2d96
https://pubmed.ncbi.nlm.nih.gov/7786161

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Detection of chemical mutagens using Muta Mouse: a transgenic mouse model

Autor: L. L. Custer, J.A. Gossen, A. J. W. Hoorn, D. Brusick, J. Vijg, B. C. Myhr

Publikováno v: Mutagenesis. 8(1)

A transgenic mouse strain with a high copy number of rescuable lacZ sequences was evaluated for its effectiveness in detecting lacZ- mutations in selected tissues. Procarbazine, cyclophosphamide, ethylnitrosourea, 7,12-dimethylbenz[a]anthracene (DMBA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2e93926d0d0248bd6e052454f3c96e
https://pubmed.ncbi.nlm.nih.gov/8450770

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