Výsledky vyhledávání - "D. Boucherot"

Synthesis and structure-activity relationships of new cephalosporins with aminoimidazoles at C-7. Effect of the pKa of the C-7 aminoimidazole on antibacterial spectrum and .BETA.-lactamase stability

Autor: G. M. Davies, A. Olivier, F. Jung, J. F. Kingston, J. D. Pittam, D. Boucherot, M. Joseph, C. Delvare, R. Brown, M. J. Betts, R. Stevenson

Publikováno v: The Journal of Antibiotics. 46:992-1012

Cephalosporins with new aminoimidazole heterocycles at C-7 have been synthesized by reaction of anti-alpha-aminooximes with C-7 dihaloisocyanocephalosporins esters or by direct condensation of 2-fluoroimidazoles with C-7 aminocephalosporins esters. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347e5bd9cd8900cbcdf0266228486805
https://doi.org/10.7164/antibiotics.46.992

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Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and .beta.-lactamase stability on the pKa of the C-7 heterocycle

Autor: N. Ackerley, C. Delvare, A. Hamon, D. Boucherot, F. Jung, M. J. Betts

Publikováno v: Journal of Medicinal Chemistry. 34:1110-1116

Cephalosporins with new aminobenzimidazole and aminoimidazoline heterocycles at C-7 have been synthesized starting with versatile C-7 isocyanide dihalide synthons. The aminobenzimidazoles have a broad spectrum of antibacterial activity, including Gra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a92e4b203e0f2978585af4ba25ed73d
https://doi.org/10.1021/jm00107a035

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Synthesis and structure-activity relationships of cephalosporins with C-3' catechol-containing residues

Autor: T. G. C. Bird, Frederic Henri Jung, J. P. Bailey, J. J. Lohmann, W. Bell, A. Olivier, A. Bertrandie, G. M. Davies, J. C. Arnould, D. Boucherot

Publikováno v: Journal of medicinal chemistry. 35(14)

Cephalosporins with new catechol substituents at C-3' have been synthesized, including novel compounds with C-3' carbon-carbon bonds. Many of these compounds have high potency against Gram-negative bacteria, in particular against resistant strains li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca7b3821b8f5dfd3e2c35891f685a87
https://pubmed.ncbi.nlm.nih.gov/1635062

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Cephalosporins with C-7-isocyanide dihalides : useful synthons for the introduction of amino heterocycles at C-7 - new routes to the synthesis of amino imidazoles

Autor: A. Hamon, D. Boucherot, F. Jung, C. Delvare

Publikováno v: Tetrahedron Letters. 30:2375-2378

Isocyanide dibromides 2 are new cephalosporin synthons, useful in the synthesis of a variety of compounds bearing amino heterocycles at C-7 (Scheme 1 ). In particular amino imidazoles 5 have been obtained from 2 via novel, mild approaches (Scheme 2 )

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::994260c15ede42153b0e1ea1b6663193
https://doi.org/10.1016/s0040-4039(01)80403-2

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A new approach to the synthesis of amino imidazoles application to the cephalosporin series

Autor: F. Jung, D. Boucherot, A. Olivier, F. Loftus

Publikováno v: Tetrahedron Letters. 30:2379-2382

A new, mild approach to amino imidazole 10 starting from the silylated carbodiimide 9 and weakly basic amine 12 is described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::531902fc0beac530fc2dcef04664e777
https://doi.org/10.1016/s0040-4039(01)80404-4

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Synthesis of 2,3-benzo-1-oxaoctem-4-carboxylic acid

Autor: D. Boucherot, W.R. Pilgrim

Publikováno v: Tetrahedron Letters. 20:5063-5066

The synthesis, in a form suitable for biological testing, of the parent compound 4 of a new series of tricyclic β-lactams is described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aed852f09dd15eb8053c4156340f51b2
https://doi.org/10.1016/s0040-4039(01)86790-3

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