Zobrazeno 1 - 10
of 542
pro vyhledávání: '"D. Borden"'
Autor:
F. Christopher Peritore-Galve, Izumi Kaji, Anna Smith, Lauren M. Walker, John A. Shupe, M. Kay Washington, Holly M. Scott Algood, Pradeep K. Dudeja, James R. Goldenring, D. Borden Lacy
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTBackground & Aim Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired diarrhea and pseudomembranous colitis. Two protein toxins, TcdA and TcdB, produced by C. difficile are the major determinants of disease. Howe
Externí odkaz:
https://doaj.org/article/24d8cbb83eb34a299947e37b96105dfe
Autor:
Hannah M. Lunnemann, Nicolas G. Shealy, Michelle L. Reyzer, John A. Shupe, Emily H. Green, Uswah Siddiqi, D. Borden Lacy, Mariana X. Byndloss, Nicholas O. Markham
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTThe mouse cecum has emerged as a model system for studying microbe-host interactions, immunoregulatory functions of the microbiome, and metabolic contributions of gut bacteria. Too often, the cecum is falsely considered as a uniform organ wit
Externí odkaz:
https://doaj.org/article/cf947e7888d24002ac4d1f911649f213
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Clostridioides difficile is a Gram-positive bacterium that can cause mild to severe diarrhea, inflammation, and colonic tissue damage in animal hosts. Symptoms of the disease can be attributed to the activity of toxin B (TcdB) secreted by C.
Externí odkaz:
https://doaj.org/article/dff8cf7d0a5a476c9c8025648277e4fe
Publikováno v:
mSphere, Vol 7, Iss 3 (2022)
ABSTRACT Clinical disease from Clostridioides difficile infection can be mediated by two toxins and their neighboring regulatory genes located within the five-gene pathogenicity locus (PaLoc). We provide several lines of evidence that the cytotoxicit
Externí odkaz:
https://doaj.org/article/af015dea3b664b419ccd55adf7c274c6
Autor:
Maribeth R Nicholson, Jacob M Parnell, Irtiqa Fazili, Sarah C. Bloch, D. Borden Lacy, Eric Skaar, Kathryn M Edwards
Publikováno v:
Journal of Clinical and Translational Science, Vol 4, Pp 150-150 (2020)
OBJECTIVES/GOALS: In 2017, new guidelines recommended multi-step algorithms for CDI diagnosis, and clinical centers rapidly implemented changes despite limited pediatric data. We assessed a multi-step algorithm using NAAT followed by EIA for ability
Externí odkaz:
https://doaj.org/article/2a330c0a95544bd3a989a490aff9452c
Autor:
Ryan Craven, D. Borden Lacy
Publikováno v:
mSphere, Vol 1, Iss 1 (2016)
ABSTRACT Clostridium sordellii infections cause gangrene and edema in humans and gastrointestinal infections in livestock. One of the principle virulence factors is TcsL, a large protein toxin which glucosylates host GTPases to cause cytopathic and c
Externí odkaz:
https://doaj.org/article/55346b51151e48caaabab25e992876e8
Autor:
Kateryna Nabukhotna, Shannon L Kordus, John A Shupe, Rubén Cano Rodríguez, Anna Smith, Julia K Bohannon, M Kay Washington, D Borden Lacy
Publikováno v:
PLoS Pathogens, Vol 20, Iss 9, p e1012568 (2024)
Clostridioides difficile is a spore-forming pathogen and the most common cause of healthcare-associated diarrhea and colitis in the United States. Besides producing the main virulence factors, toxin A (TcdA) and toxin B (TcdB), many of the common cli
Externí odkaz:
https://doaj.org/article/e4b4bb5a738b4efeab523e61d2c2ba67
Correction: Toxin B Causes Epithelial Cell Necrosis through an Autoprocessing-Independent Mechanism.
Autor:
Nicole M. Chumbler, Melissa A. Farrow, Lynne A. Lapierre, Jeffrey L. Franklin, David B. Haslam, James R. Goldenring, D. Borden Lacy
Publikováno v:
PLoS Pathogens, Vol 8, Iss 12 (2012)
Externí odkaz:
https://doaj.org/article/0fd4bb42eafe44d385a99a4cc0a41aec
Autor:
Rory Nelson Pruitt, D. Borden eLacy
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 2 (2012)
Clostridium difficile is a toxin-producing bacterium that is a frequent cause of hospital-acquired and antibiotic-associated diarrhea. The incidence, severity, and costs associated with C. difficile associated disease are substantial and increasing,
Externí odkaz:
https://doaj.org/article/d46c499f7ab04b6f9403e7589a1e85e8
Autor:
Heather M Scobie, Darran J Wigelsworth, John M Marlett, Diane Thomas, G. Jonah A Rainey, D. Borden Lacy, Marianne Manchester, R. John Collier, John A. T Young
Publikováno v:
PLoS Pathogens, Vol 4, Iss 10 (2008)
Externí odkaz:
https://doaj.org/article/6a51c75405104e29aa2fdef4481f4e7b