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Publikováno v:
Neuropharmacology. 34:541-551
It has been suggested that general anesthesia might arise as a consequence of increased cytoplasmic free ionized calcium concentration ([Ca2+]i). The effect of increased [Ca2+]i might be to activate K+ channels or to modulate other ion channels impor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b051ce0d8a1f769dbef94962c93071b2
https://doi.org/10.1016/0028-3908(95)00022-x
https://doi.org/10.1016/0028-3908(95)00022-x
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e254e42c35cbe5879ad748ddc7e8bd31
https://doi.org/10.1002/chin.199807213
https://doi.org/10.1002/chin.199807213
Autor:
D. Bleakman, R. J. Naftalin
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 258:G377-G390
Fluid and solute movements across rabbit distal colonic mucosa were investigated to determine the solute concentration of the absorbate and to characterize the absorption process. With isotonic mucosal and serosal bathing solutions the osmolality of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87dea9c9d1446580b61fab252c0ec60c
https://doi.org/10.1152/ajpgi.1990.258.3.g377
https://doi.org/10.1152/ajpgi.1990.258.3.g377
Autor:
D. Bleakman
Publikováno v:
Cellular and molecular life sciences : CMLS. 56(7-8)
Glutamate is the primary neurotransmitter in the central nervous system. One of the classes of ionotropic glutamate receptors is kainate receptors. Recent developments in the pharmacology of kainate receptors have resulted in the emergence of several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3f1a007fe03e075eea59218921acf2
https://pubmed.ncbi.nlm.nih.gov/11212306
https://pubmed.ncbi.nlm.nih.gov/11212306
Publikováno v:
Neuropharmacology. 37(1)
In a cell line (C2D7) stably expressing the human N-type calcium channel encoded by the subunits alpha1B-a, beta1b, alpha2bdelta, we have analysed the Ca2+ currents produced by a range of action potential-like voltage protocols (APVPs). Such protocol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9670cd4a9438f445747830b8033f9861
https://pubmed.ncbi.nlm.nih.gov/9680260
https://pubmed.ncbi.nlm.nih.gov/9680260
Autor:
D Bleakman, R D Bartlett, D Lodge, A R Chamberlin, Richard J. Bridges, C L Willis, D A Wacker
Publikováno v:
Journal of neurochemistry. 68(4)
A photolabile trifluoromethyldiazoketone derivative of kainate (KA), (2'S,3'S,4'R)-2'-carboxy-4'-(2-diazo-1-oxo-3, 3,3-trifluoropropyl)-3'-pyrrolidinyl acetate (DZKA), was synthesized and evaluated as an irreversible inhibitor of the high-affinity KA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75898f1102c37c236439718c0059bde
https://pubmed.ncbi.nlm.nih.gov/9084420
https://pubmed.ncbi.nlm.nih.gov/9084420
Publikováno v:
Radiation research. 138(3)
Calcium is required as a cofactor by primer recognition proteins involved in DNA synthesis and by protein kinase C (PKC), which is activated by ionizing radiation. Because these processes may be involved in radiation-mediated regulation of the progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37e57ed2af0d8265b78cc0da898e2076
https://pubmed.ncbi.nlm.nih.gov/8184014
https://pubmed.ncbi.nlm.nih.gov/8184014
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 265(2)
We examined the effects of neuropeptide Y (NPY) and pancreatic polypeptide on calcium currents (ICa) in acutely dissociated neurons from the adult rat superior cervical ganglion. We found that NPY inhibited the ICa with an estimated IC50 value of 140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c246a911cf028fa4ebc0962a1dc7ebe
https://pubmed.ncbi.nlm.nih.gov/8098766
https://pubmed.ncbi.nlm.nih.gov/8098766