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Integrating High-Dimensional Transcriptomics and Image Analysis Tools into Early Safety Screening: Proof of Concept for a New Early Drug Development Strategy

Autor: Ilse Van den Wyngaert, Willem Talloen, Bie Verbist, Steffen Jaensch, Freddy Van Goethem, Geert R. Verheyen, Marjolein Crabbe, Liesbet Vervoort, Steven Osselaer, D. Beerens, Hinrich W. H. Göhlmann, Cindy Bosmans, Geert Van Hecke, Dirk Wuyts

Publikováno v: Chemical Research in Toxicology. 28:1914-1925

During drug discovery and development, the early identification of adverse effects is expected to reduce costly late-stage failures of candidate drugs. As risk/safety assessment takes place rather late during the development process and due to the li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73edfa52b246d16f884a9ba1022a8c1c
https://doi.org/10.1021/acs.chemrestox.5b00103

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Akademický článek

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Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites

Autor: William M. Jones, Mark S. Tichenor, Sean Brown, Natalie A. Hawryluk, James A. Palmer, Lin Luo, Marlies De Boeck, Filip Woestenborghs, J. Guy Breitenbucher, Michelle Wennerholm, Joan Pierce, D. Beerens, Michael Webb, John M. Keith, Sandy J. Wilson, Jeff Merit, Sandra R. Chaplan, Mark Seierstad, Mark J. Karbarz

Publikováno v: Bioorganicmedicinal chemistry letters. 22(24)

The structure-activity relationships for a series of heteroaryl urea inhibitors of fatty acid amide hydrolase (FAAH) are described. Members of this class of inhibitors have been shown to inactivate FAAH by covalent modification of an active site seri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea6e5b07e1184539d6ba6edc8acf15c
https://pubmed.ncbi.nlm.nih.gov/23141911

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Inhibiting effect of ammonia on citric acid-induced cough in pigs: a possible involvement of substance P

Autor: B, Moreaux, A, Nemmar, D, Beerens, P, Gustin

Publikováno v: Pharmacologytoxicology. 87(6)

The effect of ammonia on the cough response to citric acid and on substance P release from C-fibers involved in this reflex was assessed. For a period from one to four days, piglets were exposed, in an inhalation chamber, to ammonia at a concentratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef1bbf114b3508cba771248eeb1d9fa7
https://pubmed.ncbi.nlm.nih.gov/11140827

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Chronic exposure of pigs to airborne dust and endotoxins in an environmental chamber: technical note

Autor: B, Urbain, J F, Prouvost, D, Beerens, O, Michel, B, Nicks, M, Ansay, P, Gustin

Publikováno v: Veterinary research. 27(6)

A new experimental setup was developed to expose pigs to dust and airborne endotoxins in an environmental chamber, at levels liable to be encountered in pig farm buildings. The following parameters were evaluated in a chamber containing two pigs of 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::36e121965ec95d46bd860aa308ab59fa
https://pubmed.ncbi.nlm.nih.gov/8956472

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Akademický článek

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Potency and selectivity of the aromatase inhibitor R 76,713. A study in human ovarian, adipose stromal, testicular and adrenal cells

Autor: D. Beerens, R. Doolaege, R. De Coster, J.A. Gruwez, W. Wouters, K. J. Van Camp, B. van Herendael, H. van der Pas

Publikováno v: Journal of steroid biochemistry. 36(1-2)

The effects of R 76 713 on steroidogenesis were studied in primary cultures of four different human cell types i.e. ovarian granulosa cells, adipose stromal cells, testicular cells and adrenal cells. In human granulosa cells aromatization of [lβ,2β

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f581abbec60e7565b2563dd7b9d5f45b
https://pubmed.ncbi.nlm.nih.gov/2362449

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Akademický článek

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Akademický článek

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Effects of high-dose ketoconazole and dexamethasone on ACTH-stimulated adrenal steroidogenesis in orchiectomized prostatic cancer patients

Autor: C. Mahler, C. Haelterman, M.-C. Coene, R. De Coster, Willem K. Amery, L. Denis, Ivo Caers, D. Beerens

Publikováno v: Acta Endocrinologica. 115:265-271

The effects of high-dose ketoconazole (i.e. 400 mg every 8 h) therapy on adrenal steroidogenesis were investigated in 7 patients with advanced prostatic cancer who no longer responded to orchiectomy. An ACTH challenge was performed before and on days

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300fd409ca8d0267d42016bfe6c34d96
https://doi.org/10.1530/acta.0.1150265

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