Zobrazeno 1 - 10
of 50
pro vyhledávání: '"D. Becherer"'
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
D C Cooper, M L Bergquist, Pat Wheelan, K I MacKenzie, Sean Ross, Mir Hashim, J D Becherer, Don L. Anderson, B Z Desai, Daniel G. Lang, Xiaozhou Yao, Maggie S. McIntyre
Publikováno v:
British Journal of Pharmacology. 154:1446-1456
Background and purpose: Drug-induced prolongation of the QT interval can lead to torsade de pointes, a life-threatening ventricular arrhythmia. Finding appropriate assays from among the plethora of options available to predict reliably this serious a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e2b9101dff4148be1f380d000b84782
https://doi.org/10.1038/bjp.2008.267
https://doi.org/10.1038/bjp.2008.267
Publikováno v:
European Journal of Pharmacology. 519:208-211
Propranolol is a noncardioselective beta-adrenergic antagonist that has been recently reported to prolong the QTc interval on the surface electrocardiogram in humans when overdosed [Farhangi, V., Sansone, R.A. (2003). QTc prolongation due to proprano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ccbb5540eea0c4336197e90e0fc2a4
https://doi.org/10.1016/j.ejphar.2005.05.010
https://doi.org/10.1016/j.ejphar.2005.05.010
Publikováno v:
Biochemical Journal. 347:131-138
Tumour necrosis factor α convertase (TACE) is a metalloprotease/disintegrin involved in the ectodomain shedding of several proteins, a process thought to be important in inflammation, rheumatoid arthritis and murine development. The characterization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a204b61235f387ca8c95ce799cd0b340
https://doi.org/10.1042/bj3470131
https://doi.org/10.1042/bj3470131
Autor:
P. A. Fernandez, Michael Schröter, Jean-Claude Martinou, R. Sadoul, J. D. Becherer, Martin Irmler, A. L. Quiquerez, Masatoshi Maki, I. Martinou, Juerg Tschopp
Publikováno v:
Europe PubMed Central
Sympathetic neurons undergo programmed cell death (PCD) upon deprivation of nerve growth factor (NGF). PCD of neurons is blocked by inhibitors of the interleukin-1beta converting enzyme (ICE)/Ced-3-like cysteine protease, indicating involvement of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49837116559ac2850145379bd2f7eda4
https://doi.org/10.1002/j.1460-2075.1996.tb00758.x
https://doi.org/10.1002/j.1460-2075.1996.tb00758.x
Autor:
Raymond I. Myers, C. Castellano, M. Tsao, N. R. Ghormley, F. Fontana, D. W. Larsen, L. D. Becherer, G. Meier
Publikováno v:
Optometry and Vision Science. 68:776-782
The purposes of this study were to determine if the quantity of protein deposited (QPD) upon hydrogel lenses was affected by enzymatic cleaning and to test the potential relation between QPD and visible protein deposition (VPD) and change. Seventy-fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cfb49437ede18d694fb02c026edd0d
https://doi.org/10.1097/00006324-199110000-00003
https://doi.org/10.1097/00006324-199110000-00003
Autor:
J G, Conway, R C, Andrews, B, Beaudet, D M, Bickett, V, Boncek, T A, Brodie, R L, Clark, R C, Crumrine, M A, Leenitzer, D L, McDougald, B, Han, K, Hedeen, P, Lin, M, Milla, M, Moss, H, Pink, M H, Rabinowitz, T, Tippin, P W, Scates, J, Selph, S A, Stimpson, J, Warner, J D, Becherer
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 298(3)
Tumor necrosis factor-alpha (TNF)-converting enzyme (TACE) cleaves the precursor form of TNF, allowing the mature form to be secreted into the extracellular space. GW3333, a dual inhibitor of TACE and matrix metalloproteinases (MMPs), was compared wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50836d54042647696574068bd0ddb75e
https://pubmed.ncbi.nlm.nih.gov/11504783
https://pubmed.ncbi.nlm.nih.gov/11504783
Publikováno v:
The Biochemical journal.
Tumour necrosis factor alpha convertase (TACE) is a metalloprotease/disintegrin involved in the ectodomain shedding of several proteins, a process thought to be important in inflammation, rheumatoid arthritis and murine development. The characterizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6888bc144a7041514007077b6faa7795
https://pubmed.ncbi.nlm.nih.gov/10727411
https://pubmed.ncbi.nlm.nih.gov/10727411
Publikováno v:
Handbook of Experimental Pharmacology ISBN: 9783642630231
Tumor necrosis factor (TNF)-α is a potent pro-inflammatory agent produced primarily by activated monocytes and macrophages (VASSALLI 1992). Originally thought to be a selective anti-tumor agent (OLD 1985) and a contributor to cachexia in cancer pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::382798f1abf07fa8db2b4de7af3d6040
https://doi.org/10.1007/978-3-642-57092-6_13
https://doi.org/10.1007/978-3-642-57092-6_13
Autor:
P E, Dekkers, F N, Lauw, T, ten Hove, A A, te Velde, P, Lumley, D, Becherer, S J, van Deventer, T, van der Poll
Publikováno v:
Blood. 94(7)
Tumor necrosis factor-alpha (TNF-alpha) is released from the cell surface by cleavage of pro-TNF-alpha by metalloproteinases (MPs). In cell cultures, inhibition of MPs has been found not only to reduce the release of TNF-alpha, but also to enhance th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b80e7e5d8b53d3f8cd8e5c7828d45b2e
https://pubmed.ncbi.nlm.nih.gov/10498596
https://pubmed.ncbi.nlm.nih.gov/10498596