Zobrazeno 1 - 10 of 69 pro vyhledávání: '"D. B. Whitehouse"'
1
Genetics of four plasma protein loci in Equus przewalskii: new alleles at the prealbumin, postalbumin and transferrin loci
Autor: W. Putt, D. B. Whitehouse
Publikováno v: Animal Blood Groups and Biochemical Genetics. 14:7-16
Summary This paper reports genetic variation at the prealbumin (Pr), postalbumin (Pa) and transferrin (Tf) loci in Equus przewalskii found using thin layer isoelectric focusing and an amphoteric separator. The method resolves all three loci plus seru
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af047230b227092307217850284e4da2
https://doi.org/10.1111/j.1365-2052.1983.tb01055.x
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2
Alpha1-Antitrypsin as a Risk for Infant and Adult Respiratory Outcomes in a National Birth Cohort
Autor: Lynne E. Vinall, Warren S. Hilder, Jennifer U. Lovegrove, Suzanne Butterworth, Rebecca Hardy, Dallas M. Swallow, Abigail L. Jones, Michael E. J. Wadsworth, D. B. Whitehouse
Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 31:559-564
Reduced alpha1-antitrypsin (AAT) encoded by the gene SERPINA1 is a potential risk for pulmonary disease. We investigated SERPINA1 polymorphism as a risk for infant and adult pulmonary morbidity, and adult respiratory function and its change between 4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6079be503d16d901aabb3f7e060ae8
https://doi.org/10.1165/rcmb.2004-0027oc
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3
Recombination hotspots and block structure of linkage disequilibrium in the human genome exemplified by detailed analysis of PGM1 on 1p31
Autor: Naheed A. Rana, Neil D. Ebenezer, D. B. Whitehouse, Andrés Ruiz Linares, Andrew R. Webster, Alison J. Hardcastle, Sue Povey
Publikováno v: Human Molecular Genetics. 13:3089-3102
The distribution of linkage disequilibrium (LD) in the human genome has important consequences for the design of experiments that infer susceptibility genes for complex disease using association studies. Recent studies have shown a non-random distrib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af2caf5c7b14e3a2137a47fe82c2490
https://doi.org/10.1093/hmg/ddh337
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4
Identification of α1-Antitrypsin Variants in Plasma with the Use of Proteomic Technology
Autor: Kevin Mills, Bryan Winchester, D. B. Whitehouse, Peter E. Clayton, Philippa B. Mills, Andrew W. Johnson
Publikováno v: Clinical Chemistry. 47:2012-2022
Background: Proteomic technology permits the investigation of genetic metabolic diseases at the level of protein expression. Changes in the expression, polypeptide structure, and posttranslational modification of individual proteins can be detected i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97467108c1108b3f2c18b076f964a1f5
https://doi.org/10.1093/clinchem/47.11.2012
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5
Anti-neutrophil cytoplasmic antibodies (ANCA) against bactericidal/permeability-increasing protein (BPI) and cystic fibrosis lung disease
Autor: N R Carroll, David A. Lomas, D Bilton, D B Whitehouse, R I Ross-Russell, R C Westerbeek, L Sharples, C M Lockwood, A C Dunn, A K Webb, Ravi Mahadeva
Publikováno v: Clinical and Experimental Immunology. 117:561-567
SUMMARY Persistent infection with Pseudomonas aeruginosa and inflammatory mechanisms play an important role in cystic fibrosis (CF) lung disease. ANCA against BPI, a potent host defence protein with anti-bacterial and anti-endotoxin properties, have
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452035e9c70d1e2006b403c54f8dd02a
https://doi.org/10.1046/j.1365-2249.1999.01006.x
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6
Mapping Recombination Hotspots in Human Phosphoglucomutase (PGM1)
Autor: J U Lovegrove, D. A. Hopkinson, D. B. Whitehouse, Shea Ping Yip, Naheed A. Rana
Publikováno v: Human Molecular Genetics. 8:1699-1706
Human phosphoglucomutase (PGM1) is a highly poly-morphic protein. Three mutations and four intragenic recombination events between the three mutation sites generate eight protein variants including the four universally common alleles, 1+, 1 -, 2+ and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aeae5e66b68598da9b5b0b0509d1245
https://doi.org/10.1093/hmg/8.9.1699
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8
A new alpha 1-antitrypsin mutation, Thr–Met 85, (PI Zbristol) associated with novel electrophoretic properties
Autor: J U Lovegrove, I. K. Temple, G. T. Gillett, Susan Povey, S. Jeremiah, D. B. Whitehouse
Publikováno v: Annals of Human Genetics. 61:385-391
A new AAT allele (PI Zbristol) has been discovered in a woman with an obstetric history of three perinatal deaths from fulminant liver disease and no living offspring. She and her father were both PI M1Zbristol heterozygotes. The Zbristol protein is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e618581938b9004a2fdd7e298043334
https://doi.org/10.1017/s0003480097006404
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10
Molecular and cytological investigations of phosphoglucomutase (PGM1) in the K562 cell line
Autor: J U Lovegrove, J. Tomkins, Jennifer M. Parrington, Margaret Fox, D. A. Hopkinson, D. B. Whitehouse
Publikováno v: Annals of Human Genetics. 61:99-108
Phosphoglucomutase 1 (PGM1) deficiency is a stable characteristic of the erythroleukaemic cell line, K562, whereas the activity of the isozymes of the other two PGM loci (PGM2 and PGM3) is slightly elevated. In this study the molecular basis of PGM1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59fda31756256ed434d443d1621cde1e
https://doi.org/10.1046/j.1469-1809.1997.6120099.x
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