Zobrazeno 1 - 10
of 10
pro vyhledávání: '"D. B. Wainscott"'
Autor:
E. Sanders‐Bush, David L. Nelson, Steve R. Waldman, Danuta Marona-Lewicka, David E. Nichols, Aaron Monte, D. B. Wainscott
Publikováno v:
ChemInform. 29
Autor:
K, Rasmussen, D O, Calligaro, J F, Czachura, L J, Dreshfield-Ahmad, D C, Evans, S K, Hemrick-Luecke, M J, Kallman, W T, Kendrick, J D, Leander, D L, Nelson, C D, Overshiner, D B, Wainscott, M C, Wolff, D T, Wong, T A, Branchek, J M, Zgombick, Y C, Xu
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 294(2)
LY426965 [(2S)-(+)-1-cyclohexyl-4-[4-(2-methoxyphenyl)-1-piperazinyl]2-methyl- 2-phenyl-1-butanone monohydrochloride] is a novel compound with high affinity for the cloned human 5-hydroxytryptamine (HT)(1A) receptor (K(i) = 4.66 nM) and 20-fold or gr
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 359(1)
Since the classical hallucinogens were initially reported to produce their behavioral effects via a 5-HT2 agonist mechanism (i.e., the 5-HT2 hypothesis of hallucinogen action), 5-HT2 receptors have been demonstrated to represent a family of receptors
Publikováno v:
European journal of pharmacology. 352(1)
To determine the potency and efficacy of 5-HT1F receptor ligands, a [35S]GTPgammaS binding assay was developed and optimized for the human 5-HT1F receptor. Compounds which are known to be effective in the abortive treatment of migraine were tested fo
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 276(2)
The 5-Hydroxytryptamine2B (5-HT2B) receptor was cloned originally from rat stomach fundus and its pharmacology was determined to be consistent with that of the receptor responsible for contraction of rat fundal tissue in response to 5-HT. Recently, t
Publikováno v:
Molecular pharmacology. 46(2)
Clones encoding a portion of the human 5-hydroxytryptamine (5-HT)2B receptor gene were isolated from a human placental genomic library. Based on distribution studies of 5-HT2B receptor mRNA, human uterus cDNA libraries were constructed and screened,
Autor:
M L, Cohen, M P, Johnson, K W, Schenck, A, Susemichel, D B, Wainscott, D W, Robertson, D L, Nelson
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 266(2)
Both alpha-methylserotonin and 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) are agonists at 5-hydroxytryptamine2 (5-HT2) receptors. The present study compared these agonists for their binding affinities at the high- and low-affinity states of
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 265(3)
Species differences in the recognition of a series of ergolines by the 5-hydroxytryptamine2 (5-HT2, serotonin2) receptor were investigated in four species, the rat, pig, squirrel monkey and human. In pig frontal cortical membranes the initial studies
Autor:
D B, Wainscott, M L, Cohen, K W, Schenck, J E, Audia, J S, Nissen, M, Baez, J D, Kursar, V L, Lucaites, D L, Nelson
Publikováno v:
Molecular pharmacology. 43(3)
The rat 5-hydroxytryptamine (5-HT)2F (serotonin2F) receptor is a newly cloned member of the 5-HT2/1C receptor family. The pharmacology of the 5-HT2F receptor was explored using a variety of structurally different compounds in a radioligand binding as
Publikováno v:
Molecular pharmacology. 42(4)
Using the polymerase chain reaction amplification technique in conjunction with conventional cloning techniques, we have isolated a novel member of the serotonin [5-hydroxytryptamine (5-HT)] 1C/2 receptor subfamily (designated 5-HT2F) from rat stomac