Zobrazeno 1 - 10
of 83
pro vyhledávání: '"D. Arndts"'
Publikováno v:
Neuropharmacology. 40:233-241
A new substance (R,S)-(3,4-dihydro-6,7-dimethoxyisoquinoline-1-yl)-2-cyclohexyl-N-(3,3-diphenylpropyl)-acetamide hydrochloride (BIIA388Cl), which demonstrates neuroprotective properties in animal models, was examined for its action on K + currents in
Publikováno v:
Molecular pharmacology. 43(5)
A pharmacological classification of receptor-activated nonselective cation channels has not been possible because of the lack of specific and potent pharmacological blockers. In dibutyryl-cAMP-differentiated HL-60 cells, we recently identified ATP- a
Autor:
D, Arndts, G, Wollnitz
Publikováno v:
Versicherungsmedizin. 42(1)
The inflation in hospital financing has fallen off. The new regulations brought in with the health reform law (Gesundheitsreformgesetz) could help to cut hospital running costs and lead to a more economical form of medical treatment. At present a pro
Publikováno v:
Life Sciences. 52:571
Publikováno v:
European Journal of Clinical Pharmacology. 24:21-30
Using considerably improved analytical methods, the kinetics and effects of clonidine were observed in healthy volunteers over periods of time more than 3 times longer than those previously reported. The high sensitivity and small work load of the ne
Publikováno v:
Journal of Pharmacological Methods. 6:109-120
A new precise and sensitive radioimunoassay (RIA) for alinidine (N-allyl-clonidine) has been developed. Synthesis and analysis of the hapten (4-carboxy-alinidine = STH 2329), as well as the production of the antibody in rabbits, are described in deta
Publikováno v:
Journal of Pharmacological Methods. 6:295-307
A radioimmunoassay for clonidine was optimized by introducing, as a tracer ligand, an iodinized clonidine derivative specifically labeled with more than 500 Ci/mMol. The detection limit of clonidine was 10 pg/ml. The high assay specificity was demons
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 6:225-236
Radioactively labelled alinidine was administered intravenously (10 mg) and orally (40 mg) to 5 healthy volunteers and beagle dogs (3 animals for each administration route: 0.1 mg/kg body weight i.v. and 1 mg/kg body weight p.o.). Alinidine was total
Publikováno v:
British Journal of Clinical Pharmacology. 13:821-827
1 Alinidine (N-allyl clonidine) pharmacokinetics were investigated in healthy volunteers following acute administration of 40 mg orally and intravenously (i.v.) and chronic administration of 40 mg daily and twice daily for 8 days. 2 After acute oral
Publikováno v:
British Journal of Clinical Pharmacology. 16:451-455
Five healthy volunteers (mean age 20.6 years, mean weight 71 kg) received in random order on day 1 and day 8 a single dose of alinidine 40 mg, clonidine 0.1 mg or placebo and on days 2-7 alinidine 40 mg, clonidine 0.1 mg or placebo given three times