Chemosensitizing acridones: In vitro calmodulin dependent cAMP phosphodiesterase inhibition, docking, pharmacophore modeling and 3D QSAR studies

Autor: G. Deepak Reddy, G.J. Peters, V.V.S. Rajendra Prasad, Y.C. Mayur, D. Appaji

Publikováno v: Journal of Molecular Graphics and Modelling, 40, 116-124. Elsevier Inc.
Prasad, V V S R, Reddy, G D, Appaji, D, Peters, G J & Mayur, Y C 2013, ' Chemosensitizing acridones: In vitro calmodulin dependent cAMP phosphodiesterase inhibition, docking, pharmacophore modeling and 3D QSAR studies ', Journal of Molecular Graphics and Modelling, vol. 40, pp. 116-124 . https://doi.org/10.1016/j.jmgm.2012.12.009

Calmodulin inhibitors have proved to play a significant role in sensitizing MDR cancer cells by interfering with cellular drug accumulation. The present investigation focuses on the evaluation of in vitro inhibitory efficacy of chloro acridones again

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https://research.vumc.nl/en/publications/45a6cd88-4562-4b67-9d56-efeb18105b47