Zobrazeno 1 - 10
of 40
pro vyhledávání: '"D. Allen Annis"'
Autor:
Sarah E. Woodfield, Yan Shi, Roma H. Patel, Zhenghu Chen, Aayushi P. Shah, Richard S. Whitlock, Aryana M. Ibarra, Samuel R. Larson, Stephen F. Sarabia, Andrew Badachhape, Zbigniew Starosolski, Ketan B. Ghaghada, Pavel Sumazin, D. Allen Annis, Dolores López-Terrada, Sanjeev A. Vasudevan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Hepatoblastoma (HB) is the most common pediatric liver malignancy. High-risk patients have poor survival, and current chemotherapies are associated with significant toxicities. Targeted therapies are needed to improve outcomes and patient qu
Externí odkaz:
https://doaj.org/article/2c835b5e701047a99457ad48818f16a6
Autor:
Samuel Y. Ng, Noriaki Yoshida, Amanda L. Christie, Mahmoud Ghandi, Neekesh V. Dharia, Joshua Dempster, Mark Murakami, Kay Shigemori, Sara N. Morrow, Alexandria Van Scoyk, Nicolas A. Cordero, Kristen E. Stevenson, Maneka Puligandla, Brian Haas, Christopher Lo, Robin Meyers, Galen Gao, Andrew Cherniack, Abner Louissaint, Valentina Nardi, Aaron R. Thorner, Henry Long, Xintao Qiu, Elizabeth A. Morgan, David M. Dorfman, Danilo Fiore, Julie Jang, Alan L. Epstein, Ahmet Dogan, Yanming Zhang, Steven M. Horwitz, Eric D. Jacobsen, Solimar Santiago, Jian-Guo Ren, Vincent Guerlavais, D. Allen Annis, Manuel Aivado, Mansoor N. Saleh, Amitkumar Mehta, Aviad Tsherniak, David Root, Francisca Vazquez, William C. Hahn, Giorgio Inghirami, Jon C. Aster, David M. Weinstock, Raphael Koch
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
T- and NK-cell lymphomas (TCL) are a group of lymphoid malignancies characterized by poor prognosis, but the absence of appropriate pre-clinical models has hampered the development of effective therapies. Here the authors establish several pre-clinic
Externí odkaz:
https://doaj.org/article/ecc83cf960564bd2938fc055d45d8a01
Author Correction: MDM4 inhibition: a novel therapeutic strategy to reactivate p53 in hepatoblastoma
Autor:
Sarah E. Woodfield, Yan Shi, Roma H. Patel, Zhenghu Chen, Aayushi P. Shah, Rohit K. Srivastava, Richard S. Whitlock, Aryana M. Ibarra, Samuel R. Larson, Stephen F. Sarabia, Andrew Badachhape, Zbigniew Starosolski, Ketan B. Ghaghada, Pavel Sumazin, D. Allen Annis, Dolores López-Terrada, Sanjeev A. Vasudevan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/4d0f9217fca3401482d0f49ebd128ace
Autor:
Galina Selivanova, John Inge Johnsen, D. Allen Annis, Lisa S. Westerberg, Mariana M.S. Oliveira, Yue Zhan, Manuel Aivado, Luis A. Carvajal, Vincent Guerlavais, Gema Sanz Santos, Madhurendra Singh, Xiaolei Zhou
References for supplementary methods file
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0ed448aac60a4538b62cc059238edd
https://doi.org/10.1158/2159-8290.22540232.v1
https://doi.org/10.1158/2159-8290.22540232.v1
Autor:
Galina Selivanova, John Inge Johnsen, D. Allen Annis, Lisa S. Westerberg, Mariana M.S. Oliveira, Yue Zhan, Manuel Aivado, Luis A. Carvajal, Vincent Guerlavais, Gema Sanz Santos, Madhurendra Singh, Xiaolei Zhou
P53 CHIP-SEQ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d0a367b500ee66238ecfeec7d5f38e
https://doi.org/10.1158/2159-8290.22540229
https://doi.org/10.1158/2159-8290.22540229
Autor:
Galina Selivanova, John Inge Johnsen, D. Allen Annis, Lisa S. Westerberg, Mariana M.S. Oliveira, Yue Zhan, Manuel Aivado, Luis A. Carvajal, Vincent Guerlavais, Gema Sanz Santos, Madhurendra Singh, Xiaolei Zhou
The repression of repetitive elements is an important facet of p53's function as a guardian of the genome. Paradoxically, we found that p53 activated by MDM2 inhibitors induced the expression of endogenous retroviruses (ERV) via increased occupancy o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1fef0ce4d0fafc94719ed54d6cf50f
https://doi.org/10.1158/2159-8290.c.6549320.v1
https://doi.org/10.1158/2159-8290.c.6549320.v1
Autor:
Galina Selivanova, John Inge Johnsen, D. Allen Annis, Lisa S. Westerberg, Mariana M.S. Oliveira, Yue Zhan, Manuel Aivado, Luis A. Carvajal, Vincent Guerlavais, Gema Sanz Santos, Madhurendra Singh, Xiaolei Zhou
All Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae2c07cecd38648234ebea4a587fe19
https://doi.org/10.1158/2159-8290.22540238
https://doi.org/10.1158/2159-8290.22540238
Publikováno v:
Nature Reviews Chemistry. 5:62-71
Affinity selection-mass spectrometry (AS-MS) is a high-throughput screening (HTS) technique for drug discovery that enables rapid screening of large collections of compounds to identify ligands for a specific biomolecular target. AS-MS is a binding a
Author Correction: MDM4 inhibition: a novel therapeutic strategy to reactivate p53 in hepatoblastoma
Autor:
Aryana M. Ibarra, Samuel R. Larson, Andrew Badachhape, Aayushi P. Shah, Yan Shi, Stephen F. Sarabia, D. Allen Annis, Rohit Kumar Srivastava, Pavel Sumazin, Roma H. Patel, Dolores Lopez-Terrada, Richard S. Whitlock, Zbigniew Starosolski, Sanjeev A. Vasudevan, Sarah E. Woodfield, Ketan B. Ghaghada, Zhenghu Chen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Autor:
Mansoor N. Saleh, Manish R. Patel, Todd M. Bauer, Sanjay Goel, Gerald S. Falchook, Geoffrey I. Shapiro, Ki Y. Chung, Jeffrey R. Infante, Robert M. Conry, Guilherme Rabinowits, David S. Hong, Judy S. Wang, Ulrich Steidl, Loren D. Walensky, Gurudatta Naik, Vincent Guerlavais, Vojislav Vukovic, D. Allen Annis, Manuel Aivado, Funda Meric-Bernstam
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 27(19)
Purpose: We describe the first-in-human dose-escalation trial for ALRN-6924, a stabilized, cell-permeating peptide that disrupts p53 inhibition by mouse double minute 2 (MDM2) and MDMX to induce cell-cycle arrest or apoptosis in TP53-wild-type (WT) t