Zobrazeno 1 - 10
of 40
pro vyhledávání: '"D. Alan Underhill"'
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Chromatin is thought to regulate the accessibility of the underlying DNA sequence to machinery that transcribes and repairs the DNA. Heterochromatin is chromatin that maintains a sufficiently high density of DNA packing to be visible by light microsc
Externí odkaz:
https://doaj.org/article/1d835f4c5a8f4242805193b78d98b551
Autor:
John Maringa Githaka, Namita Tripathi, Raven Kirschenman, Namrata Patel, Vrajesh Pandya, David A. Kramer, Rachel Montpetit, Lin Fu Zhu, Nahum Sonenberg, Richard P. Fahlman, Nika N. Danial, D. Alan Underhill, Ing Swie Goping
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Preventing phosphorylation of BAD (3SA) in mouse models and human cells inhibits mammary gland development, acting by disrupting 4E-BP1- mediated translation and affecting focal adhesion/protrusion stability, cell migration and ductal tubulogenesis.
Externí odkaz:
https://doaj.org/article/da9677ace6fa4ee0a7b417531c2a2ab1
Autor:
Hilmar Strickfaden, Natnael Abate, Christian Förster, Frank Wuest, D Alan Underhill, Michael J Hendzel
Publikováno v:
Microscopy.
Transmission electron microscopy (TEM) has been essential in defining the structural organization of the cell due to its ability to image cell structures at molecular resolution. However, the absence of colour has made it very difficult to compare th
Autor:
Hilmar Strickfaden, Justin W. Knechtel, D. Alan Underhill, Michael J. Hendzel, Kristal Missiaen
SUMMARYCells use multiple strategies to compartmentalize functions through a combination of membrane- bound and membraneless organelles. The latter represent complex assemblies of biomolecules that coalesce into a dense phase through low affinity, mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06e8e7753f42e816dd4afcffd6fab93c
https://doi.org/10.1101/2021.11.04.467369
https://doi.org/10.1101/2021.11.04.467369
Autor:
Lin Fu Zhu, Vrajesh Pandya, Raven Kirschenman, Namita Tripathi, Namrata Patel, Nika N. Danial, John Maringa Githaka, David A. Kramer, Rachel Montpetit, Nahum Sonenberg, D. Alan Underhill, Ing Swie Goping, Richard P. Fahlman
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Elucidation of non-canonical protein functions can identify novel tissue homeostasis pathways. Herein, we describe a role for the Bcl-2 family member BAD in postnatal mammary gland morphogenesis. In Bad3SA knock-in mice, where BAD cannot undergo phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5bd5fcca741a8bd55d9fd92b80db1b1
https://escholarship.org/uc/item/5mg5h2b9
https://escholarship.org/uc/item/5mg5h2b9
Autor:
Hilmar Strickfaden, Jeffrey C. Hansen, Thomas O. Tolsma, Ajit Sharma, D. Alan Underhill, Michael J. Hendzel
Publikováno v:
Cell. 183(7)
Summary The association of nuclear DNA with histones to form chromatin is essential for temporal and spatial control of eukaryotic genomes. In this study, we examined the physical state of condensed chromatin in vitro and in vivo. Our in vitro studie
Autor:
Jordan W. Squair, David D.W. Twa, Kirill Zaslavsky, Lynn A Raymond, Alexandra Kuzyk, Mark J Eisenberg, Jennifer X Ji, Ève-Reine Gagné, Norman D. Rosenblum, Xin Wang, Patrick E. Steadman, Ayan K. Dey, James F Lewis, Peter J Margetts, Kent T HayGlass, Michael A. Skinnider, D Alan Underhill
Publikováno v:
CMAJ Open. 5:E308-E314
Background Combined MD/PhD programs provide a structured path for physician-scientist training, but assessment of their success within Canada is limited by a lack of quantitative data. We collected outcomes data for graduates of Canadian MD/PhD progr
Publikováno v:
Neurotherapeutics. 14:274-283
Progress in the treatment of adult high-grade gliomas (HGG), including chemoradiation with concurrent and adjuvant temozolomide for glioblastoma, has not translated into significant therapeutic advances for pediatric HGG, where overall survival has p
The PAX (paired box) family is a collection of metazoan transcription factors defined by the paired domain, which confers sequence-specific DNA-binding. Ancestral PAX proteins also contained a homeodomain, which can communicate with the paired domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0baeed845f863a10f37f64779092933
https://doi.org/10.1101/701656
https://doi.org/10.1101/701656
Autor:
Gareth N. Corry, Juan Ausió, Darin McDonald, Hilmar Strickfaden, John Th'ng, Michèle Rouleau, Guy G. Poirier, Toyotaka Ishibashi, Jean-François Haince, Michael J. Kruhlak, D. Alan Underhill, Michael J. Hendzel
Publikováno v:
Journal of Biological Chemistry. 291:1789-1802
Chromatin undergoes a rapid ATP-dependent, ATM and H2AX-independent decondensation when DNA damage is introduced by laser microirradiation. Although the detailed mechanism of this decondensation remains to be determined, the kinetics of decondensatio