Výsledky vyhledávání

Akademický článek

The effect of ultrasonic vibrations with superimposed low-frequency modulation on the mechanical, tribological properties and structure of a multicomponent polymer composite

Autor: D. A. Negrov, V. Yu. Putintsev, A. I. Glotov, D. A. Veber

Publikováno v: Омский научный вестник: Серия "Авиационно-ракетное и энергетическое машиностроение", Vol 7, Iss 4, Pp 79-84 (2023)

One of the tasks of polymer materials science is to study the possibilities of improving the complex of elastic-strength characteristics and tribological properties of polymer composite materials by improving the manufacturing technology. In this p

Externí odkaz: https://doaj.org/article/300b36040228437dacdd62947f60b59f

Zobrazit plný text záznamu

Amide and α-keto carbonyl inhibitors of thrombin based on arginine and lysine: Synthesis, stability and biological characterization

Autor: K.J. Stauffer, Jules A. Shafer, Stephen F. Brady, S. D. Lewis, John T. Sisko, D. F. Veber, Howard Qiu, Assunta S. Ng, Ruth F. Nutt, Michael J. Bogusky, Christiana D. Colton

Publikováno v: Bioorganic & Medicinal Chemistry. 3:1063-1078

We report structure-activity investigations in a series of tripeptide amide inhibitors of thrombin, and the development of a series of highly potent active site directed α-keto carbonyl inhibitors having the side chain of lysine at P1. Compounds of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f9bc2f83708b3dcd8fa0cec0f08ae3
https://doi.org/10.1016/0968-0896(95)00105-p

Zobrazit plný text záznamu

Potent dual antagonists of endothelin and angiotensin II receptors derived from α-phenoxyphenylacetic acids (Part III)

Autor: Thomas F. Walsh, Nancy A. Nolan, Douglas J. Pettibone, William J. Greenlee, Stacey O'Malley, Raymond S.L. Chang, Kenneth J. Fitch, D. F. Veber, David L. Williams, Kathryn L. Murphy, Bradley V. Clineschmidt

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:1155-1158

Screening a collection of α-phenoxyphenylacetic acid derived angiotensin II antagonists identified weak actives in an endothelin receptor binding assay. Synthetic modification of one of these leads has provided L-746,072 (13), a highly potent dual a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4cbeefcb6363c63409cfc7f93562c70e
https://doi.org/10.1016/0960-894x(95)00186-w

Zobrazit plný text záznamu

Non-peptide oxytocin antagonists: identification and synthesis of a potent camphor aminosuccinimide

Autor: N. P. Gould, James B. Hoffman, D. F. Veber, Doug W. Hobbs, Doug J. Pettibone, Roger M. Freidinger, Bradley V. Clineschmidt

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:119-122

The structure activity relationships of a series of non-peptide oxytocin antagonists containing a camphor aminosuccinimide as a key structural element were investigated. A potent and selective analog was identified and prepared in diastereomerically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cee920a0809a31c3a6fea178922f61c
https://doi.org/10.1016/0960-894x(94)00469-v

Zobrazit plný text záznamu

Selective non-peptide ligands for an accommodating peptide receptor. Imidazobenzodiazepines as potent cholecystokinin type b receptor antagonists

Autor: Alison J. Smith, D. F. Veber, Robert M. DiPardo, Randall C. Newton, Kerry L. Chapman, Smita Patel, Mark G. Bock, Jeffrey M. Bergman, Roger M. Freidinger, George R. Marshall, John A. Kemp, Stephen B. Freedman

Publikováno v: Bioorganic & Medicinal Chemistry. 2:987-998

A series of imidazobenzodiazepines, non-peptide antagonists of the peptide hormone cholecystokinin (CCK), are described. Derived by chemical modification of the benzodiazepine ring system embedded within the CCK-B antagonist L-365,260, these compound

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa43f3d5dc40299092462924e88ae759
https://doi.org/10.1016/s0968-0896(00)82047-7

Zobrazit plný text záznamu

L-368,899, a potent orally active oxytocin antagonist for potential use in preterm labor

Publikováno v: Drug Development Research. 30:129-142

L-368,899 [1S-(-7,7-dimethyl-2-endo-(2S-amino-4-(methylsulfonyl)butyramido)-bicyclo(2.2.1)-heptan-1-yl)methanesulfonyl)-4-(2-methylphenyl)piperazine] was characterized in vitro and in vivo as a potent and selective, orally bioavailable oxytocin (OT)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2d543025961ee32823042a54971256b
https://doi.org/10.1002/ddr.430300305

Zobrazit plný text záznamu

The solution conformation Ac-Pen-Arg-Gly-Asp-Cys-OH, a potent fibrinogen receptor antagonist

Autor: D. F. Veber, Steven M. Pitzenberger, Stephen F. Brady, Christiane D. Colton, Michael E. Mertzman, Michael J. Bogusky, Ruth F. Nutt, Adel M. Naylor

Publikováno v: Biopolymers. 33:1287-1297

The solution conformation of Ac-Pen-Arg-Gly-Asp-Cys-OH, a potent fibrinogen receptor antagonist, was characterized in DMSO-d6 by the combination of nmr and molecular modeling. The conformational space available to the peptide was explored using a dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5410d3a80f41ade22f249e3450bb4ca
https://doi.org/10.1002/bip.360330813

Zobrazit plný text záznamu

Benzolactams as non-peptide cholecystokinin receptor ligands

Autor: Mark G. Bock, Stephen B. Freedman, Robert M. DiPardo, Victor J. Lotti, Raymond S.L. Chang, Roger M. Freidinger, D. F. Veber

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:871-874

A series of 1,3-substituted benzolactams are reported which are nonpeptidal receptor ligands of the peptide hormone cholecystokinin (CCK). These compounds are composites of potent, selective benzolactam CCK-A antagonists and unique structural element

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69f5eca8e01c780a62f2bb99c08b4609
https://doi.org/10.1016/s0960-894x(00)80683-6

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání