Zobrazeno 1 - 10
of 199
pro vyhledávání: '"D. A. Upson"'
Autor:
D. A. Upson
Publikováno v:
Journal of Polymer Science: Polymer Symposia. 72:45-54
Examples of functional monomers and latex polymers are described. Use of functional monomers allows great versatility in the design of latex polymers with specialized properties. Included are examples of electrophilic, nucleophilic, crosslinkable, hy
Autor:
A. Yawman, T.J. Caulfield, W.C. Schairer, C.V.C. Prasad, Prouty Catherine P, Ashis K. Saha, L. I. Kruse, D. A. Upson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:411-414
A stereoselective method for the synthesis of 3′-α-or 3′-β-carbon substituted pyrimidine nucleosides was developed. The synthesis of the CH 2 NHCH 2 linkage is described. The linkage offers enhanced resistance to 3′-exonuclease.
Autor:
D. A. Upson, T.J. Caulfield, Prouty Catherine P, C.V.C. Prasad, D.J. Delecki, Ashis K. Saha, L. I. Kruse
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1497-1500
The synthesis of an O-CH2-CH2 internucleoside linkage has been achieved. The crucial carbon to oxygen bond was formed by trapping a π-allyl palladium complex with 3' alcohol6. An antisense oligonucleoside containing this dimer modification hybridize
Autor:
D. A. Upson, W.C. Schairer, L. I. Kruse, M. Sardaro, T.J. Caulfield, Ashis K. Saha, C.V.C. Prasad, A. Yawman, Prouty Catherine P
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2771-2776
The synthesis of CH2-CH2-NH and NH-CH2-CH2 internucleoside linkages are described. Antisense oligonucleosides containing these dimer modifications hybridized to the sense sequence. Furthermore incorporation of these backbone modifications enhanced th
Publikováno v:
Tetrahedron Letters. 34:8411-8414
Substituted thymidine derivatives are of interest because of their potential antiviral properties. We demonstrate a general strategy for synthesis of 3′-substituted thymidine derivatives, consisting of activation via N-3 alkylation of 2,3′-cyclot
Autor:
Ashis K. Saha, M. Sardaro, C.V.C. Prasad, D. A. Upson, L. I. Kruse, C. Waychunas, W.C. Schairer
Publikováno v:
ChemInform. 25
Publikováno v:
ChemInform. 25
Substituted thymidine derivatives are of interest because of their potential antiviral properties. We demonstrate a general strategy for synthesis of 3′-substituted thymidine derivatives, consisting of activation via N-3 alkylation of 2,3′-cyclot
Autor:
L. I. Kruse, P. Cavanaugh, D.J. Delecki, D. A. Upson, Ashis K. Saha, M. Sardaro, A. Yawman, C. Waychunas, R. Kutny
Publikováno v:
ChemInform. 25
Publikováno v:
Veterinary Clinics of North America: Food Animal Practice. 7:633-649
Aspects of drug disposition, metabolism, and toxicity in the ruminant animal are discussed, and illustrative examples are provided. The effects of the reticulo-rumen on drug disposition in the ruminant are highlighted.
Autor:
James A. Gainor, David A. Whipple, M. A. Ator, D. A. Upson, Barry A. Morgan, Martin P. Allen, Thomas D. Gordon, Adi M. Treasurywala, J. E. Solowiej, Jasbir Singh
Publikováno v:
Journal of Medicinal Chemistry. 38:217-219