Zobrazeno 1 - 10
of 90
pro vyhledávání: '"D. A. Rawlings"'
Autor:
D J Rawlings, Catherine A Bonn, Mark A. Birch-Machin, Bhaven Chavan, Eyman Rashdan, Laura Hudson
Publikováno v:
The FASEB Journal
The ability of solar ultraviolet (UV) to induce skin cancer and photoaging is well recognized. The effect of the infrared (IR) and visible light (Vis) components of solar radiation on skin and their interaction with UV is less well known. This study
Publikováno v:
Journal of Osteoporosis, Vol 2011 (2011)
Introduction. Femoral neck shaft angle (NSA) has been reported to be an independent predictor of hip fracture risk in men. We aimed to assess the role of NSA in UK men. Methods. The NSA was measured manually from the DXA scan printout in men with hip
Externí odkaz:
https://doaj.org/article/3d4adfc4326c40369ef1983a78d372a9
Autor:
Claire L Wood, Tim Cheetham, Michelle Eagle, D J Rawlings, Michela Guglieri, Catherine J. Owen, Kate Bushby, Volker Straub, Aura Cecilia Jimenez Moreno, Anna Mayhew, Anna Sarkozy, Ramesh C. Srinivasan
Publikováno v:
Muscle & Nerve. 54:79-85
Introduction We assessed prophylactic use of bisphosphonate (BP) in Duchenne muscular dystrophy (DMD) patients on glucocorticoid (GC) therapy. Methods Fifty-two DMD patients on daily GC were offered BP (oral risedronate). Patients were reviewed for t
Publikováno v:
Stem cells (Dayton, Ohio). 36(4)
Autor:
Graham Hart, D J Rawlings
Publikováno v:
Physica Medica. 32:281-282
Introduction Measurement of staff radiation exposure to ultraviolet (UV) radiation in Dermatology and other Departments currently relies on measurements using fixed detecting equipment. Although staff do not usually receive direct UV exposure, they m
Autor:
Sheryl Mitchell, Fraser Birrell, R. Peaston, D J Rawlings, Elizabeth A. Lingard, Andrew McCaskie, Roger M. Francis
Publikováno v:
Age and Ageing. 39:234-239
Background: the presence of osteoporosis in patients with hip and knee osteoarthritis (OA) has important implications for understanding disease progression and providing optimal surgical and medical management. Objective: to determine the prevalence
Publikováno v:
Acta Orthopaedica. 80:660-665
Background Resurfacing is a popular alternative to a standard hip replacement in young arthritic patients. Despite bone preservation around the femoral component, there is little information regard...
Autor:
Adrian Hall, Tiziana Scoccitti, Christopher Budd, Alan Naylor, D. Anthony Rawlings, David N. Hurst, Alex W. Wilson, Nicholas Maughan Clayton, Thomas George Christopher Hayhow, Susan H. Brown, Wendy J. Winchester, Gerard Martin Paul Giblin, Paul Goldsmith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:497-501
Herein we describe the medicinal chemistry programme to identify a potential back-up compound to the EP1 receptor antagonist GW848687X. This work started with the lipophilic 1,2-biaryl benzene derivative 4 which displayed molecular weight of 414.9 g/
Autor:
Ian R. Kilford, Andy Billinton, Barry Passingham, Anita Chowdhury, Alan Naylor, Adrian Hall, Gerard Martin Paul Giblin, Thomas George Christopher Hayhow, Leanne Cutler, Paul Goldsmith, Susan H. Brown, Alan K. Bristow, D. Anthony Rawlings
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4027-4032
We describe the discovery of a series of pyrazole amide EP1 receptor antagonists with good aqueous solubility and CNS penetration. In order to achieve solubility we investigated the incorporation of a basic group in the region of the molecule previou
Autor:
Celestine T. O'Shaughnessy, Gerard Martin Paul Giblin, Brian Peter Slingsby, Carl Haslam, Alan Naylor, Andrew John Eatherton, Alex W. Wilson, and Andrew R. Wittington, Nick M. Clayton, Richard D. Green, Paul Goldsmith, William L. Mitchell, D. Anthony Rawlings, Andrew J. Brown, Iain P. Chessell
Publikováno v:
Journal of Medicinal Chemistry. 50:2597-2600
Selective CB2 receptor agonists are promising potential therapeutic agents for the treatment of inflammatory and neuropathic pain. A focused screen identified a pyrimidine ester as a partial agonist at the CB2 receptor with micromolar potency. Subseq