Zobrazeno 1 - 10
of 476
pro vyhledávání: '"D. A. Pritchard"'
Autor:
Ngu Wah Than, D. Mark Pritchard, David M. Hughes, Kai Shing Yu, Helen S. Minnaar, Amandeep Dhadda, Jamie Mills, Joakim Folkesson, Calin Radu, C.A. Duckworth, Helen Wong, Muneeb Ul Haq, Rajaram Sripadam, Mark D. Halling-Brown, Alexandra J. Stewart, Arthur Sun Myint
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 49, Iss , Pp 100851- (2024)
Background and purpose: Radical surgery is the standard of care for early rectal cancer. However, alternative organ-preserving approaches are attractive, especially in frail or elderly patients as these avoid surgical complications. We have assessed
Externí odkaz:
https://doaj.org/article/e94040b3366b45e39646e1e4bbf99ec1
Autor:
Louis Gall, Ferran Jardi, Lieve Lammens, Janet Piñero, Terezinha M. Souza, Daniela Rodrigues, Danyel G. J. Jennen, Theo M. deKok, Luke Coyle, Seung‐Wook Chung, Sofia Ferreira, Heeseung Jo, Kylie A. Beattie, Colette Kelly, Carrie A. Duckworth, D. Mark Pritchard, Carmen Pin
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 10, Pp 1511-1528 (2023)
Abstract We have built a quantitative systems toxicology modeling framework focused on the early prediction of oncotherapeutic‐induced clinical intestinal adverse effects. The model describes stem and progenitor cell dynamics in the small intestina
Externí odkaz:
https://doaj.org/article/ad07b2f07f9e481a9365795b33099f08
Autor:
Margarita Karageorgou, David M. Hughes, Arthur Sun Myint, D. Mark Pritchard, Laura J. Bonnett
Publikováno v:
Diagnostic and Prognostic Research, Vol 6, Iss 1, Pp 1-5 (2022)
Abstract Background Rectal cancer has a high prevalence. The standard of care for management of localised disease involves major surgery and/or chemoradiotherapy, but these modalities are sometimes associated with mortality and morbidity. The notion
Externí odkaz:
https://doaj.org/article/15f60526dcfa42b998b7b650ea6bdc11
Autor:
Claudio Durán, Sara Ciucci, Alessandra Palladini, Umer Z. Ijaz, Antonio G. Zippo, Francesco Paroni Sterbini, Luca Masucci, Giovanni Cammarota, Gianluca Ianiro, Pirjo Spuul, Michael Schroeder, Stephan W. Grill, Bryony N. Parsons, D. Mark Pritchard, Brunella Posteraro, Maurizio Sanguinetti, Giovanni Gasbarrini, Antonio Gasbarrini, Carlo Vittorio Cannistraci
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Drug use or bacterial infection can cause significant alterations of gastric microbiome. Here, the authors show how advanced pattern recognition by nonlinear machine intelligence can help disclose a bacteria-metabolite network which enlightens mechan
Externí odkaz:
https://doaj.org/article/1a4e3dda819d41df95b04fd64ec82e28
Autor:
Katie A. Lloyd, Bryony N. Parsons, Michael D. Burkitt, Andrew R. Moore, Stamatia Papoutsopoulou, Malcolm Boyce, Carrie A. Duckworth, Klaire Exarchou, Nathan Howes, Lucille Rainbow, Yongxiang Fang, Claus Oxvig, Steven Dodd, Andrea Varro, Neil Hall, D. Mark Pritchard
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 1, Pp 113-132 (2020)
Background & Aims: In patients with autoimmune atrophic gastritis and achlorhydria, hypergastrinemia is associated with the development of type 1 gastric neuroendocrine tumors (gNETs). Twelve months of treatment with netazepide (YF476), an antagonist
Externí odkaz:
https://doaj.org/article/fa9e77fa8ab04349aa617d5d954be8d7
Autor:
Stephane Bourgeois, Daniel F. Carr, Crispin O. Musumba, Alexander Penrose, Celestine Esume, Andrew P. Morris, Andrea L. Jorgensen, J. Eunice Zhang, D. Mark Pritchard, Panos Deloukas, Munir Pirmohamed
Publikováno v:
EBioMedicine, Vol 74, Iss , Pp 103728- (2021)
ABSTRACT: Background: Low-dose aspirin can cause gastric and duodenal ulceration, hereafter called peptic ulcer disease (PUD). Predisposition is thought to be related to clinical and genetic factors; our aim was to identify genetic risk factors assoc
Externí odkaz:
https://doaj.org/article/e356fc46996447cfa33cfd26c73f0564
Autor:
Reuben Veysey-Smith, Andrew R. Moore, Senthil V. Murugesan, Laszlo Tiszlavicz, Graham J. Dockray, Andrea Varro, D. Mark Pritchard
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
BackgroundHypergastrinaemia occasionally indicates the presence of a gastrinoma. However it is much more commonly associated with various benign causes including proton pump inhibitor (PPI) use, Helicobacter pylori infection and/or atrophic gastritis
Externí odkaz:
https://doaj.org/article/0efdf513cd5b4eba921d632e19d174bc
Autor:
Ian Beales, Jan Bornschein, Peter Malfertheiner, Ariel Beresniak, D. Mark Pritchard, Hocine Salhi
Publikováno v:
BMJ Open Gastroenterology, Vol 8, Iss 1 (2021)
Objective Clinical data comparing diagnostic strategies in the management of Helicobacter pylori-associated diseases are limited. Invasive and noninvasive diagnostic tests for detecting H. pylori infection are used in the clinical care of patients wi
Externí odkaz:
https://doaj.org/article/31f1c45fc0644cefa6dcb4447022ed54
Autor:
Daniel J. Cuthbertson, Jorge Barriuso, Angela Lamarca, Prakash Manoharan, Thomas Westwood, Matthew Jaffa, Stephen W. Fenwick, Christina Nuttall, Fiona Lalloo, Andreas Prachalias, Michail Pizanias, Hulya Wieshmann, Mairead G. McNamara, Richard Hubner, Raj Srirajaskanthan, Gillian Vivian, John Ramage, Martin O. Weickert, D Mark Pritchard, Sobhan Vinjamuri, Juan Valle, Vincent S. Yip
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
ObjectivePancreatic neuroendocrine tumours (panNETs) arise sporadically or as part of a genetic predisposition syndrome. CT/MRI, endoscopic ultrasonography and functional imaging using Octreoscan localise and stage disease. This study aimed to evalua
Externí odkaz:
https://doaj.org/article/9d5e0b2e2dd24565b36a6a45e2208f71
Autor:
F. Jardi, C. Kelly, C. Teague, H. Fowler-Williams, D. C. Sevin, D. Rodrigues, H. Jo, S. Ferreira, B. Herpers, M. Van Heerden, T. de Kok, C. Pin, A. Lynch, C. A. Duckworth, S. De Jonghe, L. Lammens, D. M. Pritchard
Publikováno v:
Archives of Toxicology, 97(1), 235-254. Springer
Archives of Toxicology
Archives of Toxicology
Cross-species comparison of drug responses at the organoid level could help to determine the human relevance of findings from animal studies. To this end, we first need to evaluate the in vitro to in vivo translatability of preclinical organoids. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e749e8bf68be60e4670a50b6b93d853
https://doi.org/10.1007/s00204-022-03374-3
https://doi.org/10.1007/s00204-022-03374-3