Zobrazeno 1 - 5
of 5
pro vyhledávání: '"D. A. Konevetz"'
Autor:
Marina A. Zenkova, A. V. Malyshev, Vladimir N. Silnikov, N. V. Tamkovich, Valentin V. Vlassov, D. A. Konevetz
Publikováno v:
Russian Journal of Bioorganic Chemistry. 33:233-242
The effect of the total positive charge in the RNA-binding domain of chemical ribonucleases that are conjugates of bisquaternary salts of 1,4-diazabicylo[2.2.2]octane and imidazole on the cleavage of an HIV-1 RNA fragment was studied. An increase in
Autor:
Marina A. Zenkova, I. E. Beck, Valentin V. Vlassov, Vladimir N. Silnikov, G. V. Shishkin, D. A. Konevetz, N. L. Mironova
Publikováno v:
Russian Journal of Bioorganic Chemistry. 28:331-341
Artificial ribonucleases of the ABLkCm series were synthesized. They consist of a lipophilic alkyl radical (Et, n-C14H29, or n-C15H31) А, an “RNA-binding domain” В (bisquaternary salt of 1,4-diazabicyclo[2.2.2]octane), a “catalytic domain”
Publikováno v:
Russian Journal of Bioorganic Chemistry. 26:765-773
On the basis of imidazole and bisquaternary salts of 1,4-diazabicyclo[2.2.2]octane, a number of highly effective catalysts of thenDm series (here,n is the number of positive charges at neutral pH values andm is the digital code of the catalytically a
Publikováno v:
ChemInform. 34
The review surveys the results of our studies devoted to the design of highly efficient catalysts of hydrolysis of the phosphodiester bonds in RNA. These catalysts contain the imidazole residue in the catalytic domain, one or several bis-quaternized
Publikováno v:
Nucleic acids symposium series. (24)