Zobrazeno 1 - 10
of 528
pro vyhledávání: '"D. A. Horn"'
Autor:
Vardan Arutiunian, Megha Santhosh, Emily Neuhaus, Heather Borland, Chris Tompkins, Raphael A. Bernier, Susan Y. Bookheimer, Mirella Dapretto, Abha R. Gupta, Allison Jack, Shafali Jeste, James C. McPartland, Adam Naples, John D. Van Horn, Kevin A. Pelphrey, Sara Jane Webb
Publikováno v:
Molecular Autism, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Background Most children with Autism Spectrum Disorder (ASD) have co-occurring language impairments and some of these autism-specific language difficulties are also present in their non-autistic first-degree relatives. One of the possible ne
Externí odkaz:
https://doaj.org/article/2a915911ffab4dd7894744918d7e1457
Autor:
Emily G. Saccuzzo, Mubark D. Mebrat, Hailee F. Scelsi, Minjoo Kim, Minh Thu Ma, Xinya Su, Shannon E. Hill, Elisa Rheaume, Renhao Li, Matthew P. Torres, James C. Gumbart, Wade D. Van Horn, Raquel L. Lieberman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Studies of folded-to-misfolded transitions using model protein systems reveal a range of unfolding needed for exposure of amyloid-prone regions for subsequent fibrillization. Here, we probe the relationship between unfolding and aggregation
Externí odkaz:
https://doaj.org/article/d4c43b083a34447bb38dec82f348044d
Publikováno v:
Biogeosciences, Vol 20, Pp 3353-3366 (2023)
Many studies in ecohydrology focusing on hydrologic transport argue that longer residence times across a stream ecosystem should consistently result in higher biological uptake of carbon, nutrients, and oxygen. This consideration does not incorporate
Externí odkaz:
https://doaj.org/article/8359b7846bd44f1cb6666a330ed706ed
Autor:
Angela J. Okragly, Aya Ryuzoji, Isabella Wulur, Montanea Daniels, Robert D. Van Horn, Chetan N. Patel, Robert J. Benschop
Publikováno v:
Dermatology and Therapy, Vol 13, Iss 7, Pp 1535-1547 (2023)
Abstract Introduction IL-13 is the primary upregulated cytokine in atopic dermatitis (AD) skin and is the pathogenic mediator driving AD pathophysiology. Lebrikizumab, tralokinumab and cendakimab are therapeutic monoclonal antibodies (mAb) that targe
Externí odkaz:
https://doaj.org/article/dbd152b9d5754b53906c6ae3157c3648
Autor:
Paul B. Orndorff, Souvik Poddar, Aerial M. Owens, Nikita Kumari, Bryan T. Ugaz, Samrat Amin, Wade D. Van Horn, Arjan van der Vaart, Marcia Levitus
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Uracil DNA-glycosylase (UNG) is a DNA repair enzyme that removes the highly mutagenic uracil lesion from DNA using a base flipping mechanism. Although this enzyme has evolved to remove uracil from diverse sequence contexts, UNG excision effi
Externí odkaz:
https://doaj.org/article/d901f8cbb7c745719150e7b634cf7a2a
Autor:
Emily Neuhaus, Sarah J. Lowry, Megha Santhosh, Anna Kresse, Laura A. Edwards, Jack Keller, Erin J. Libsack, Veronica Y. Kang, Adam Naples, Allison Jack, Shafali Jeste, James C. McPartland, Elizabeth Aylward, Raphael Bernier, Susan Bookheimer, Mirella Dapretto, John D. Van Horn, Kevin Pelphrey, Sara Jane Webb, and the ACE GENDAAR Network
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 13, Iss 1, Pp 1-15 (2021)
Abstract Background Identification of ASD biomarkers is a key priority for understanding etiology, facilitating early diagnosis, monitoring developmental trajectories, and targeting treatment efforts. Efforts have included exploration of resting stat
Externí odkaz:
https://doaj.org/article/01d79f0ba74b4ad8aecd684ab6842835
Autor:
Zachary Jacokes, Allison Jack, Catherine A. W. Sullivan, Elizabeth Aylward, Susan Y. Bookheimer, Mirella Dapretto, Raphael A. Bernier, Daniel H. Geschwind, Denis G. Sukhodolsky, James C. McPartland, Sara J. Webb, Carinna M. Torgerson, Jeffrey Eilbott, Lauren Kenworthy, Kevin A. Pelphrey, John D. Van Horn, The GENDAAR Consortium, Katy Ankenman, Sarah Corrigan, Dianna Depedro-Mercier, Nadine Gaab, Desiree Guilford, Abha R. Gupta, Shafali Jeste, Cara M. Keifer, Anna Kresse, Erin Libsack, Jennifer K. Lowe, Erin MacDonnell, Nicole McDonald, Adam Naples, Charles A. Nelson, Emily Neuhaus, Pamela Ventola, Olivia Welker, Julie Wolf
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Autism Spectrum Disorder (ASD) is a developmental condition characterized by social and communication differences. Recent research suggests ASD affects 1-in-44 children in the United States. ASD is diagnosed more commonly in males, though it is uncle
Externí odkaz:
https://doaj.org/article/a3606502e36d49e0aeac12bb452fd062
Autor:
Tushar Modi, Valeria A. Risso, Sergio Martinez-Rodriguez, Jose A. Gavira, Mubark D. Mebrat, Wade D. Van Horn, Jose M. Sanchez-Ruiz, S. Banu Ozkan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
TEM-1 β-lactamase evolved from ancestral enzymes that degraded a variety of β-lactam antibiotics with moderate efficiency and degrades β-lactam antibiotics with a strong preference for penicillins. Here authors developed a computational approach t
Externí odkaz:
https://doaj.org/article/9f68b130500b474887f6a03663bb2f12
Autor:
Minjoo Kim, Nicholas J. Sisco, Jacob K. Hilton, Camila M. Montano, Manuel A. Castro, Brian R. Cherry, Marcia Levitus, Wade D. Van Horn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The TRPV1 ion channel is a heat-sensing receptor that is also activated by vanilloid compounds, but the molecular underpinnings of thermosensing have remained elusive. Here authors use in solution NMR on the isolated human TRPV1 S1-S4 domain and show
Externí odkaz:
https://doaj.org/article/031b403abc3941b8bfde584589cc3cd7
Publikováno v:
Agrosystems, Geosciences & Environment, Vol 4, Iss 2, Pp n/a-n/a (2021)
Abstract Riparian buffers can improve water quality, but watershed‐scale evaluations of riparian buffering opportunities are rare. A landscape discretization tool called riparian catchments, part of the Agricultural Conservation Planning Framework
Externí odkaz:
https://doaj.org/article/0f84b783469d467393eaf671e52db819