Zobrazeno 1 - 10
of 723
pro vyhledávání: '"D., de Carvalho"'
Autor:
Shengrui Feng, Sajid A. Marhon, Dustin J. Sokolowski, Alister D’Costa, Fraser Soares, Parinaz Mehdipour, Charles Ishak, Helen Loo Yau, Ilias Ettayebi, Parasvi S. Patel, Raymond Chen, Jiming Liu, Philip C. Zuzarte, King Ching Ho, Ben Ho, Shiyao Ning, Annie Huang, Cheryl H. Arrowsmith, Michael D. Wilson, Jared T. Simpson, Daniel D. De Carvalho
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Inactivating mutations in SMARCB1 confer an oncogenic dependency on EZH2 in atypical teratoid rhabdoid tumors (ATRTs), but the underlying mechanism has not been fully elucidated. We found that the sensitivity of ATRTs to EZH2 inhibition (EZH
Externí odkaz:
https://doaj.org/article/0d1e7015e2c14b349eee324205203761
Autor:
Coby Viner, Charles A. Ishak, James Johnson, Nicolas J. Walker, Hui Shi, Marcela K. Sjöberg-Herrera, Shu Yi Shen, Santana M. Lardo, David J. Adams, Anne C. Ferguson-Smith, Daniel D. De Carvalho, Sarah J. Hainer, Timothy L. Bailey, Michael M. Hoffman
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-46 (2024)
Abstract Background Transcription factors bind DNA in specific sequence contexts. In addition to distinguishing one nucleobase from another, some transcription factors can distinguish between unmodified and modified bases. Current models of transcrip
Externí odkaz:
https://doaj.org/article/e7bb424ddc9949f19963f6d42c94377b
Autor:
ARTHUR P. DA SILVA, MACÁRIO A. REBELO, RICARDO AUGUSTO BARBIERI, CARLOS D. DE CARVALHO, CAMILA DE MORAES
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 96, Iss 2 (2024)
Abstract This study is the first to apply training impulse (TRIMP) and Training Monotony (TM) methodologies, within the realm of sport science, in animal model studies. Rats were divided into Sedentary (SED, n=10) and Training (TR, n=13). TR performe
Externí odkaz:
https://doaj.org/article/64f60bb55e94473b86e0eae8014f089e
Autor:
Julcileia Imara D De Carvalho Muenho, Marisol Peña Sanchez, Alina González-Quevedo Monteagudo, Danay Martínez Puentes, Sergio González García, Marianela Arteche Prior, Asdrubal Arias Morales
Publikováno v:
Medisur, Vol 21, Iss 5, Pp 1014-1023 (2023)
Foundation: depression in ischemic cerebrovascular disease is one of the most frequent non-neurological complications.Objective: to determine the association of inflammatory markers and endothelial dysfunction with depression in patients with ischemi
Externí odkaz:
https://doaj.org/article/ce1439b065574908b4f3a74bdb5c364c
Autor:
Amir Hosseini, Håvard T. Lindholm, Raymond Chen, Parinaz Mehdipour, Sajid A. Marhon, Charles A. Ishak, Paul C. Moore, Marie Classon, Andrea Di Gioacchino, Benjamin Greenbaum, Daniel D. De Carvalho
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113684- (2024)
Summary: Viral mimicry describes the immune response induced by endogenous stimuli such as double-stranded RNA (dsRNA) from endogenous retroelements. Activation of viral mimicry has the potential to kill cancer cells or augment anti-tumor immune resp
Externí odkaz:
https://doaj.org/article/674108447e304d77b6317639adec0da5
Autor:
Ana Nikolic, Francesca Maule, Anna Bobyn, Katrina Ellestad, Seungil Paik, Sajid A. Marhon, Parinaz Mehdipour, Xueqing Lun, Huey-Miin Chen, Claire Mallard, Alexander J. Hay, Michael J. Johnston, Christopher J. Gafuik, Franz J. Zemp, Yaoqing Shen, Nicoletta Ninkovic, Katalin Osz, Elodie Labit, N. Daniel Berger, Duncan K. Brownsey, John J. Kelly, Jeff Biernaskie, Peter B. Dirks, Darren J. Derksen, Steven J. M. Jones, Donna L. Senger, Jennifer A. Chan, Douglas J. Mahoney, Daniel D. De Carvalho, Marco Gallo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Self-renewal is a crucial property of glioblastoma cells that is enabled by the choreographed functions of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could therefore represent
Externí odkaz:
https://doaj.org/article/028fa80da48448499589471060a20e19
Autor:
Sujun Chen, Jessica Petricca, Wenbin Ye, Jiansheng Guan, Yong Zeng, Nicholas Cheng, Linsey Gong, Shu Yi Shen, Junjie T. Hua, Megan Crumbaker, Michael Fraser, Stanley Liu, Scott V. Bratman, Theodorus van der Kwast, Trevor Pugh, Anthony M. Joshua, Daniel D. De Carvalho, Kim N. Chi, Philip Awadalla, Guoli Ji, Felix Feng, Alexander W. Wyatt, Housheng Hansen He
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Metastatic prostate cancer can be difficult to biopsy and characterise. Here, the authors use cell-free DNA methylation analysis to illustrate changes in hypermethylation in metastatic disease.
Externí odkaz:
https://doaj.org/article/7b26255c7880443b834672c94a98b048
Autor:
Tiago S. Medina, Alex Murison, Michelle Smith, Gabriela S. Kinker, Ankur Chakravarthy, Glauco A. F. Vitiello, Williams Turpin, Shu Yi Shen, Helen L. Yau, Olga F. Sarmento, William Faubion, Mathieu Lupien, Mark S. Silverberg, Cheryl H. Arrowsmith, Daniel D. De Carvalho
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe imbalance between Th17 and regulatory T cells in inflammatory bowel diseases (IBD) promotes intestinal epithelial cell damage. In this scenario, T helper cell lineage commitment is accompanied by dynamic changes to the chromatin that
Externí odkaz:
https://doaj.org/article/48032f330d2f4012b81f6e5ecfa9adc0
Akademický článek
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Autor:
Samantha L. Wilson, Shu Yi Shen, Lauren Harmon, Justin M. Burgener, Tim Triche, Jr., Scott V. Bratman, Daniel D. De Carvalho, Michael M. Hoffman
Publikováno v:
Cell Reports: Methods, Vol 2, Iss 9, Pp 100294- (2022)
Summary: Cell-free methylated DNA immunoprecipitation sequencing (cfMeDIP-seq) identifies genomic regions with DNA methylation, using a protocol adapted to work with low-input DNA samples and with cell-free DNA (cfDNA). We developed a set of syntheti
Externí odkaz:
https://doaj.org/article/8df9a2a8c6e84980b59dbd24e459a70f