A Single L/D-Substitution at Q4 of the mInsA2-10 Epitope Prevents Type 1 Diabetes in Humanized NOD Mice

Autor: Mengjun Zhang, Yuanqiang Wang, Xiangqian Li, Gang Meng, Xiaoling Chen, Lina Wang, Zhihua Lin, Li Wang

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Autoreactive CD8+ T cells play an indispensable key role in the destruction of pancreatic islet β-cells and the initiation of type 1 diabetes (T1D). Insulin is an essential β-cell autoantigen in T1D. An HLA-A*0201-restricted epitope of insulin A ch

Externí odkaz: https://doaj.org/article/92f23dea53084ec1a93b4c747af46943

Improved proteolytic stability of chicken cathelicidin-2 derived peptides by D-amino acid substitutions and cyclization

Autor: Edwin J.A. Veldhuizen, E.M. Molhoek, A. van Dijk, Henk P. Haagsman, Floris J. Bikker

Publikováno v: Peptides, 32(5), 875-880. Elsevier Inc.
Peptides, 32(5), 875-880. Elsevier
Peptides, 5, 32, 875-880
Molhoek, E M, van Dijk, A, Veldhuizen, E J A, Haagsman, H P & Bikker, F J 2011, ' Improved proteolytic stability of chicken cathelicidin-2 derived peptides by D-amino acid substitutions and cyclization ', Peptides, vol. 32, no. 5, pp. 875-880 . https://doi.org/10.1016/j.peptides.2011.02.017

A truncated version of host defense peptide chicken cathelicidin-2, C1-15, possesses potent, broad spectrum antibacterial activity. A variant of this peptide, F2,5,12W, which contains 3 phenylalanine to tryptophan substitutions, possesses improved an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a29c72cf1185f0a21512b1013c1ba065
https://doi.org/10.1016/j.peptides.2011.02.017

Improved proteolytic stability of chicken cathelicidin-2 derived peptides by d-amino acid substitutions and cyclization

Autor: Molhoek, E.M., van Dijk, A., Veldhuizen, E.J.A., Haagsman, H.P., Bikker, F.J., Strategic Infection Biology, LS Moleculaire Afweer, I&I SIB3

Publikováno v: Peptides, 32, 875. Elsevier

A truncated version of host defense peptide chicken cathelicidin-2, C1-15, possesses potent, broad spectrum antibacterial activity. A variant of this peptide, F2,5,12W, which contains 3 phenylalanine to tryptophan substitutions, possesses improved an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::39a6b96ec14a7cfbce5c1fbae3d9d029
https://dspace.library.uu.nl/handle/1874/231699

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