Zobrazeno 1 - 10 of 33 pro vyhledávání: '"D Zajchowski"'
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Abstract P1-13-02: Early change in topoisomerase 1 (Top1) positive circulating tumor cells (CTCs) is associated with overall survival (OS) in patients with advanced breast cancer after treatment with etirinotecan pegol
Autor: D Zajchowski, S-A Im, Darren W. Davis, Ute Hoch, S Sy, J. Cortes, Joyce A. O'Shaughnessy, Katie Caygill, E. A. Perez, L Lu, Alison L. Hannah, Chris Twelves, Ahmad Awada, HS Rugo
Publikováno v: Cancer Research. 76:P1-13
Background: Etirinotecan pegol (EP) is a long-acting Top1 inhibitor providing sustained levels of active metabolite throughout the entire chemotherapy cycle. The phase 3 BEACON trial compared EP to treatment of physician's choice (TPC) in patients wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c0593718551c863d471454ece90c546
https://doi.org/10.1158/1538-7445.sabcs15-p1-13-02
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3
Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER
Autor: Laura D. Zajchowski, Mary E. Resek, Duncan T. Browman, Stephen M. Robbins
Publikováno v: Journal of Cell Science. 119:3149-3160
Our laboratory was interested in characterizing the molecular composition of non-caveolar lipid rafts. Thus, we generated monoclonal antibodies to lipid raft proteins of human myelomonocytic cells. Two of these proteins, KE04p and C8orf2, were found
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2326719ec2d24904192f23658b1523
https://doi.org/10.1242/jcs.03060
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4
Abstract MIP-056: CONSTITUTIVELY ACTIVE ESTROGEN RECEPTOR–ALPHA LIGAND BINDING DOMAIN (ERA–LBD) MUTATIONS IN OVARIAN CARCINOMA
Autor: J. A. Elvin, L. Gay, G. Colon-Otero, M. Jorgensen, L. Havrilesky, D. Zajchowski, L Shawver, F. A. Valea, S Aithal, J. S. Ross, M. Markman, S. Gaillard
Publikováno v: Clinical Cancer Research. 23:MIP-056
OBJECTIVES: Mutations in ESR1 that are acquired following treatment with aromatase inhibitors commonly underlie resistance to endocrine therapy in breast cancer. ERa-LBD mutations, especially at ESR1 Y537 and D538, confer constitutive activity and pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3c35b4c0ab755c4f06cbb6f5c027a11
https://doi.org/10.1158/1557-3265.ovcasymp16-mip-056
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5
Tid1 is a new regulator of p53 mitochondrial translocation and apoptosis in cancer
Autor: Sung-Woo Kim, A N Elwi, L D Zajchowski, B Y Ahn, B Lee, D L N Trinh
Publikováno v: Oncogene. 29(8)
The p53 tumor suppressor protein induces apoptosis in response to genotoxic and environmental stresses. Recent studies have revealed the existence of a transcription-independent mitochondrial p53 apoptotic pathway; however, the mechanism that regulat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238480b3ea2ab324d4bf9a5d0254659e
https://pubmed.ncbi.nlm.nih.gov/19935715
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8
Lipid rafts and little caves. Compartmentalized signalling in membrane microdomains
Autor: Stephen M. Robbins, Laura D. Zajchowski
Publikováno v: European journal of biochemistry. 269(3)
Lipid rafts are liquid-ordered membrane microdomains with a unique protein and lipid composition found on the plasma membrane of most, if not all, mammalian cells. A large number of signalling molecules are concentrated within rafts, which have been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b21817859cdf72c835e4d3fb29ced1
https://pubmed.ncbi.nlm.nih.gov/11846775
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