Zobrazeno 1 - 10
of 20
pro vyhledávání: '"D Z, Ewton"'
Publikováno v:
Journal of Biological Chemistry. 266:15917-15923
Differentiation of muscle cells to form postmitotic myotubes is usually viewed as being negatively controlled by medium components, sometimes designated "mitogens." However, we have found that a family of mitogenic agents, the insulin-like growth fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d844671de4e9750958ffab4015d1e78a
https://doi.org/10.1016/s0021-9258(18)98496-6
https://doi.org/10.1016/s0021-9258(18)98496-6
Publikováno v:
International journal of cancer. 87(3)
Many human tumor cells are resistant to growth inhibition by TGF beta 1. Resistance may be caused by mutations in TGFbeta receptors or in other components of the TGF beta signal transduction systems, or by knockout of the retinoblastoma (Rb) gene, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::154950f1097c8dc0bc71dc77a4203a01
https://pubmed.ncbi.nlm.nih.gov/10897042
https://pubmed.ncbi.nlm.nih.gov/10897042
Publikováno v:
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 31(2-3)
Our previous work has demonstrated that the insulin-like growth factors (IGFs), acting through a single receptor, stimulate both proliferation and differentiation of L6A1 myoblasts. This unique model system has enabled us to closely examine the switc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783851529d1ecde9531a16fd4b4c6461
https://pubmed.ncbi.nlm.nih.gov/10226782
https://pubmed.ncbi.nlm.nih.gov/10226782
Publikováno v:
Journal of cellular physiology. 177(1)
We have previously shown that the insulin-like growth factors (IGFs) stimulate both proliferation and differentiation of skeletal muscle cells in culture, and that these actions in L6A1 muscle cells may be modulated by three secreted IGF binding prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2aef15f7801f9775737c09ada728a2d
https://pubmed.ncbi.nlm.nih.gov/9731744
https://pubmed.ncbi.nlm.nih.gov/9731744
Publikováno v:
The Journal of biological chemistry. 271(22)
It has long been known that nerves stimulate growth and maintenance of skeletal muscles in ways not dependent on physical contacts, but numerous attempts to identify and characterize the myotrophic agent(s) secreted by nerves have been unsuccessful.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5ae5e3b2f4a5d687b34c66fb265068e
https://pubmed.ncbi.nlm.nih.gov/8663030
https://pubmed.ncbi.nlm.nih.gov/8663030
Autor:
J R Florini, D Z Ewton
Publikováno v:
The Journal of endocrinology. 144(3)
It is well known that IGFs-I and -II stimulate both the proliferation and differentiation of myoblasts, but the role of the IGF binding proteins (IGFBPs) during these processes has not been established. In this study we show that IGF-I analogs with g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201bfc4c3f8e38b5857ccff4c089f6e7
https://pubmed.ncbi.nlm.nih.gov/7537792
https://pubmed.ncbi.nlm.nih.gov/7537792
Autor:
J R, Florini, D Z, Ewton
Publikováno v:
Growth regulation. 5(1)
The effects of a series of major anabolic hormones on incorporation of labeled precursors into protein and DNA were measured in cardiac myocytes from neonatal rats. IGF-I, TGF beta, and insulin all stimulated [3H] leucine incorporation into protein;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d4107e6dcd4047bc033256a9de2a0a1
https://pubmed.ncbi.nlm.nih.gov/7749347
https://pubmed.ncbi.nlm.nih.gov/7749347
Publikováno v:
Journal of cellular physiology. 161(2)
Mitogens are generally thought to inhibit myogenesis, and many cell biologists have found it hard to interpret observations that the insulin-like growth factors (IGFs) stimulate both proliferation and differentiation of muscle cells in culture. Our p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f6f66cc9c491bdd7f14771d009ab40
https://pubmed.ncbi.nlm.nih.gov/7962112
https://pubmed.ncbi.nlm.nih.gov/7962112
Publikováno v:
Endocrinology. 135(1)
We have previously reported that autocrine secretion of insulin-like growth factor-II (IGF-II) plays a critical role in stimulating spontaneous myogenic differentiation in vitro. Myogenesis and IGF-II gene expression are both negatively controlled by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335c09469312adcdb36938b88d32bf70
https://pubmed.ncbi.nlm.nih.gov/8013391
https://pubmed.ncbi.nlm.nih.gov/8013391
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461363019
We have studied the stimulation of differentiation by the IGFs for more than a decade, and have now reached a reasonably comprehensive view of this important action of these major hormones. Our recent work makes it clear that a primary mechanism invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51015e42e4bb5e8a898daa936bccde09
https://doi.org/10.1007/978-1-4615-2988-0_31
https://doi.org/10.1007/978-1-4615-2988-0_31
