Zobrazeno 1 - 10
of 113
pro vyhledávání: '"D Y, Mitchell"'
Autor:
R P, Robinson, L A, Reiter, W E, Barth, A M, Campeta, K, Cooper, B J, Cronin, R, Destito, K M, Donahue, F C, Falkner, E F, Fiese, D L, Johnson, A V, Kuperman, T E, Liston, D, Malloy, J J, Martin, D Y, Mitchell, F W, Rusek, S L, Shamblin, C F, Wright
Publikováno v:
Journal of Medicinal Chemistry. 39:10-18
Ether, ester, and carbonate derivatives of the antirheumatic oxindole 1 were prepared and screened as potential prodrugs of 1. This effort led to the discovery of the (alpha-L-alanyloxy)-methyl ether and hemifumarate derivatives of 1 which deliver th
Autor:
D Y, Mitchell, W H, Barr, R A, Eusebio, K A, Stevens, F P, Duke, D A, Russell, J D, Nesbitt, J H, Powell, G A, Thompson
Publikováno v:
Pharmaceutical research. 18(2)
To determine the pharmacokinetics and absolute bioavailability of risedronate after single-dose oral administration of 30 mg risedronate as a tablet and an aqueous solution, and 0.3 mg risedronate as an intravenous infusion.This study was a randomize
Autor:
D Y, Mitchell, R A, Eusebio, L E, Dunlap, K A, Pallone, J D, Nesbitt, D A, Russell, M E, Clay, P J, Bekker
Publikováno v:
Pharmaceutical research. 15(2)
Two studies were conducted to compare the absorption of risedronate administered as a solution to three different gastrointestinal sites (study A) and to determine the extent of absorption of risedronate solution administered by rapid and slow infusi
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 21(2)
This study was designed to determine if a relationship exists between hepatic gamma-glutamyltranspeptidase (gamma-GT) activity and the biliary excretion of glutathione (GSH) and its hydrolysis products. Rats were pretreated with the following microso
Publikováno v:
Biological mass spectrometry. 21(7)
A specific high-performance liquid chromatographic/atmospheric pressure chemical ionization tandem mass spectrometric assay for the quantitative determination of tenidap and its D3 analog in human serum is described. The assay exhibited a linear dyna
Publikováno v:
Advances in experimental medicine and biology. 284
Publikováno v:
Enzymology and Molecular Biology of Carbonyl Metabolism 3 ISBN: 9781468459036
Peroxidation of membrane lipids is thought be a dynamic process which is ongoing in virtually all cells. Under normal conditions, cellular lipid peroxidation is well regulated and, as noted in a recent review (Esterbauer. et al. , 1990), is always as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::914ac698fcb2275280df81fdbb6b413a
https://doi.org/10.1007/978-1-4684-5901-2_9
https://doi.org/10.1007/978-1-4684-5901-2_9
Publikováno v:
Clinical Pharmacology & Therapeutics. 73:P93-P93
Autor:
D Y, Mitchell, D R, Petersen
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 16(1)
Acrolein, the lowest member of the ethylenic aldehyde series, has been widely studied as a result of the diverse toxicities associated with it. Previous investigations into the enzymatic process responsible for the detoxification of acrolein implicat
Autor:
D Y, Mitchell, D R, Petersen
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 251(1)
The oxidative and reductive metabolism of the acrolein-glutathione adduct, S-(2,aldehydo-ethyl)glutathione, by rat liver aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH) was characterized. The glutathione-acrolein adduct is oxidized to t