Zobrazeno 1 - 10
of 20
pro vyhledávání: '"D Y, Loh"'
Publikováno v:
The Journal of Immunology. 157:4297-4308
Peripheral tolerance of T cells is necessary because thymic deletion is not complete, and tissue-specific Ags exist outside the thymus. We have reported that persistent Ag is required to maintain peripheral tolerance in vivo. We suspect that the TCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc44d39ea7e6dec06c56bfe9e92f629d
https://doi.org/10.4049/jimmunol.157.10.4297
https://doi.org/10.4049/jimmunol.157.10.4297
Autor:
L Van Kaer, Michael J. Chorney, D Y Loh, A. D. DeSilva, Alina Boesteanu, I Negishi, Sebastian Joyce, P Sharma
Publikováno v:
The Journal of Experimental Medicine
Thymic selection of natural killer-1+ natural T cells that express alpha beta T cell receptors requires a conserved beta 2-microglobulin-associated molecule, presumably CD1d, displayed by CD4+8+ thymocytes. Here we demonstrate that positive selection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebee6be919c0ee5ca7817199a4fb97b
https://doi.org/10.1084/jem.184.4.1579
https://doi.org/10.1084/jem.184.4.1579
Publikováno v:
The Journal of Immunology. 154:5757-5768
Naive T cells require an Ag-specific signal, as well as a costimulatory signal to mount a primary Ag-specific response. Because of their low precursor frequency, it has been difficult to study costimulatory requirements of these Ag-specific T cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bee3e861a16c527b7a7db1a1020a3201
https://doi.org/10.4049/jimmunol.154.11.5757
https://doi.org/10.4049/jimmunol.154.11.5757
Publikováno v:
Proceedings of the National Academy of Sciences. 91:3700-3704
Mice carrying ablated coding regions of the bcl-2 alpha and bcl-2 beta transcripts have been made. bcl-2-/- mutants are smaller but viable, although about half of them die by 6 weeks of age. As shown earlier with somatic bcl-2 gene-targeted mice, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267d3239c5b4da4f541970196da214ab
https://doi.org/10.1073/pnas.91.9.3700
https://doi.org/10.1073/pnas.91.9.3700
Publikováno v:
The Journal of Experimental Medicine
A cDNA library of TCR beta chain transcripts from BALB/c thymocytes was constructed using anchored polymerase chain reaction (PCR). Screening of this library led to the identification of a V beta gene segment, V beta 20, structurally related to V bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00cb0cc1c96c344ed6bf6116a326f3e
https://doi.org/10.1084/jem.174.5.1263
https://doi.org/10.1084/jem.174.5.1263
Publikováno v:
Genesdevelopment. 14(5)
SATB1 is expressed primarily in thymocytes and can act as a transcriptional repressor. SATB1 binds in vivo to the matrix attachment regions (MARs) of DNA, which are implicated in the loop domain organization of chromatin. The role of MAR-binding prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f275cc0f731bafb132c103d87209646d
https://pubmed.ncbi.nlm.nih.gov/10716941
https://pubmed.ncbi.nlm.nih.gov/10716941
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(1)
T cell unresponsiveness to Ag stimulation can be induced by several means. The precise mechanism by which this process occurs remains poorly understood. Preincubating T cells with either EDCI-fixed APC or ionomycin is a proven means of inducing T cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c1fe3f7d075ba50b598d5652470ec9e
https://pubmed.ncbi.nlm.nih.gov/9551953
https://pubmed.ncbi.nlm.nih.gov/9551953
Publikováno v:
Blood. 89(3)
To investigate the role of bcl-2 in lymphohematopoiesis, a long-term bone marrow reconstitution system was established. Transplantation of 1,000 c-Kit+ Sca-1+ and lineage markers negative cells from bcl-2-l-mouse bone marrow resulted in long-term rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c5356e754e3c944d4bc0a3c395ddddc
https://pubmed.ncbi.nlm.nih.gov/9028316
https://pubmed.ncbi.nlm.nih.gov/9028316
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 157(10)
Peripheral tolerance of T cells is necessary because thymic deletion is not complete, and tissue-specific Ags exist outside the thymus. We have reported that persistent Ag is required to maintain peripheral tolerance in vivo. We suspect that the TCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a296cf3ced72c5b83f5b56c40b96b532
https://pubmed.ncbi.nlm.nih.gov/8906803
https://pubmed.ncbi.nlm.nih.gov/8906803
Publikováno v:
Cell. 85(5)
Mice lacking p27(Kip1) have been created by gene targeting in embryonic stem cells. These mice are larger than the control animals, with thymus, pituitary, and adrenal glands and gonadal organs exhibiting striking enlargement. CDK2 activity is elevat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4d9c47194a6b9ade94a0fc4efa9c929
https://pubmed.ncbi.nlm.nih.gov/8646779
https://pubmed.ncbi.nlm.nih.gov/8646779