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Metabolism of the calcium antagonist, mibefradil (POSICOR, Ro 40-5967). Part III. Comparative pharmacokinetics of mibefradil and its major metabolites in rat, marmoset, cynomolgus monkey and man

Autor: S. R. Harris, B. M. Sutton, H. A. Welker, E. Worth, G. Heeps, H. R. Wiltshire, D. W. Angus, A. M. Betty

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 27(6)

1. The metabolism of mibefradil has been examined in rat, marmoset, cynomolgus monkey and man after single and multiple oral administration. 2. Metabolites typically represent between 50 and 80% of the circulating drug-related material after single o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f564621c1ff3e5c9bc0ee80465f50495
https://pubmed.ncbi.nlm.nih.gov/9211656

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Metabolism of the calcium antagonist, mibefradil (POSICOR, Ro 40-5967). Part II. Metabolism in hepatic microsomes from rat, marmoset, cynomolgus monkey, rabbit and man

Autor: M J Madigan, G Heeps, Hugh R. Wiltshire, A M Betty, B M Sutton, S R Sharp, D W Angus

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 27(6)

1. The calcium antagonist, mibefradil, is converted to some 30 metabolites after incubation with hepatic microsomes from the rat, marmoset, cynomolgus monkey, rabbit and man. 2. The wide inter-species differences in metabolic profile stem mainly from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14577542c6289917c9595c225ea5190f
https://pubmed.ncbi.nlm.nih.gov/9211655

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