Zobrazeno 1 - 10
of 16
pro vyhledávání: '"D W, Sickles"'
Publikováno v:
Neurotoxicology. 21(4)
Acrylamide (ACR) and g-diketones (g-DK) produce distal sensory-motor neuropathy in a variety of species, including humans. The specific molecular site and mechanism of toxicant action leading to specific morphological and behavioral abnormalities req
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1409d09ebf0de2bc4061e06f9ae908df
https://pubmed.ncbi.nlm.nih.gov/11022855
https://pubmed.ncbi.nlm.nih.gov/11022855
Publikováno v:
Journal of neuroscience research. 46(1)
Acrylamide (ACR) is an environmental toxicant and prototypic tool for studying mechanisms of peripheral neuropathies. Reductions in fast anterograde axonal transport (faAXT) are thought to be a critical step leading to axonal degeneration. Kinesin an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::11640f0689ccd3a9703d5d93001f621a
https://pubmed.ncbi.nlm.nih.gov/8892100
https://pubmed.ncbi.nlm.nih.gov/8892100
Autor:
C H, Clarke, D W, Sickles
Publikováno v:
Neurotoxicology. 17(2)
The critical axonopathy- producing effect of acrylamide (ACR) is hypothesized to be an interruption of fast vesicular transport resulting in a deficiency of distal axonal proteins. This study used the accumulation of growth associated protein- 43 (GA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a7336e0301faa753b5603564f4ccde6
https://pubmed.ncbi.nlm.nih.gov/8856736
https://pubmed.ncbi.nlm.nih.gov/8856736
Autor:
D W, Sickles
Publikováno v:
Toxicology and applied pharmacology. 108(3)
Fast anterograde axonal transport has been advanced as a potential site of action of acrylamide (ACR) and the neurotoxic gamma-diketones in producing nerve degeneration. The segmental analysis method of axonal transport was used to measure the rate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d52d43d846ecb571960d89b62e2d1fb1
https://pubmed.ncbi.nlm.nih.gov/2020966
https://pubmed.ncbi.nlm.nih.gov/2020966
Autor:
G. S. Sohal, D. W. Sickles
Publikováno v:
Development. 96:79-97
The influence of innervation on the initial differentiation of muscle fibre types was investigated by using the trochlear nucleus-superior oblique muscle system of duck. The adult muscle is composed of three types of fibres (designated as type I, II,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::482d31d857af9f611798caf7bd64d6c2
https://doi.org/10.1242/dev.96.1.79
https://doi.org/10.1242/dev.96.1.79
Autor:
Roger E. McLendon, D. W. Sickles
Publikováno v:
Histochemistry. 79:205-217
Despite the wealth of literature concerned with muscle fiber biochemical, ultrastructural and physiological characteristics, little information is available regarding the metabolic enzyme activities of α-motoneurons. The present study examines the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82b829691446d19065d55bdf43feba75
https://doi.org/10.1007/bf00489782
https://doi.org/10.1007/bf00489782
Publikováno v:
Histochemistry. 73:577-588
The present study examines the use of photographic densitometry combined with atomic absorption spectrophotometry for the quantitation of enzyme activities (SDH and ATPase) in fresh frozen sections of rat tibialis anterior muscles. The technique elim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7df81b0f36affbabef22f14f2eee6bd
https://doi.org/10.1007/bf00493370
https://doi.org/10.1007/bf00493370
Autor:
D. W. Sickles, T. G. Oblak
Publikováno v:
Journal of neurophysiology. 51(3)
We have examined the oxidative metabolism of rat alpha-motoneurons innervating muscles composed predominantly of one muscle-fiber type. Intramuscular injections of horseradish peroxidase (HRP) into the tensor fasciae latae (TFL) (approximately 94% fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529a0b2818434971ca1cf96fe870e3d4
https://pubmed.ncbi.nlm.nih.gov/6546583
https://pubmed.ncbi.nlm.nih.gov/6546583
Autor:
G S, Sohal, D W, Sickles
Publikováno v:
Journal of embryology and experimental morphology. 96
The influence of innervation on the initial differentiation of muscle fibre types was investigated by using the trochlear nucleus-superior oblique muscle system of duck. The adult muscle is composed of three types of fibres (designated as type I, II,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::51dc5fc5eaf569e82b13890f4559727a
https://pubmed.ncbi.nlm.nih.gov/2949042
https://pubmed.ncbi.nlm.nih.gov/2949042
Autor:
D. W. Sickles, J. K. Pearson
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 63(6)
Quantitative enzyme histochemical methods have been used to determine the effect of ablation of synergists on the oxidative metabolism of the alpha-motoneurons and muscle fibers of the rat soleus. Sixty days postablation, the NADH-tetrazolium reducta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d431cf3cb7c080c174d4a85df9f10b
https://pubmed.ncbi.nlm.nih.gov/3436865
https://pubmed.ncbi.nlm.nih.gov/3436865