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Responses to Aggregating Agents after Cleavage of GPIb of Human Platelets by the O-Sialoglycoprotein Endoprotease from Pasteurella haemolytica— Potential Surrogates for Bernard-Soulier Platelets?☆

Autor: Marian A. Packham, Raelene L. Kinlough-Rathbone, D W Perry, Margaret L. Rand

Publikováno v: Thrombosis Research. 99:165-172

Most proteolytic enzymes that cleave glycoprotein lb (GPlb) also cleave other glycoproteins or receptors on the surface of platelets. We have used an O-sialoglycoprotein endoprotease from Pasteurella haemolytica that selectively cleaves the heavily O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e18e382147bb3faf1b7f9c608bb630
https://doi.org/10.1016/s0049-3848(00)00240-1

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Pretreatment of Human Platelets with Plasmin Inhibits Responses toThrombin, but Potentiates Responses to Low Concentrations of Aggregating Agents, Including the Thrombin Receptor Activating Peptide, SFLLRN

Autor: Marian A. Packham, D W Perry, Margaret L. Rand, Raelene L. Kinlough-Rathbone

Publikováno v: Thrombosis and Haemostasis. 77:741-747

SummaryEffects of plasmin on platelets, that influence subsequent responses to aggregating agents, are relevant to attempts to prevent rethrombosis following administration of fibrinolytic agents. We describe plasmin-induced inhibition of platelet re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::afb4d4a22adb432ca8c40753e0cc8c15
https://doi.org/10.1055/s-0038-1656044

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Conditions influencing release of granule contents from human platelets in citrated plasma induced by ADP or the thrombin receptor activating peptide SFLLRN: Direct measurement of percent release of β-thromboglobulin and assessment by flow cytometry of P-selectin expression

Autor: Erik Yeo, Marian A. Packham, D W Perry, Raelene L. Kinlough-Rathbone, Margaret L. Rand, Cynthia H. Gemmell

Publikováno v: American Journal of Hematology. 52:288-294

Contrary to a recent report [Rinder et al.: Blood 82:505, 1993], aspirin does inhibit the release of alpha-granule contents as well as inhibiting the release of dense granule contents by human platelets during ADP-induced aggregation in citrated plat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70a07df597baaeb5f76dbbfad733d092
https://doi.org/10.1002/(sici)1096-8652(199608)52:4<288::aid-ajh8>3.0.co

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Probenecid Inhibits Platelet Responses to Aggregating Agents in Vitro and Has a Synergistic Inhibitory Effect with Penicillin G

Autor: Raelene L. Kinlough-Rathbone, Marian A. Packham, D W Perry, Deborah H. Ruben, Margaret L. Rand

Publikováno v: Thrombosis and Haemostasis. 76:239-244

SummaryProbenecid is an anion channel blocker and uricosuric agent, originally developed to slow the rate of excretion of penicillin. It is now also administered with many other drugs to reduce their required dosages. Recently, probenecid (2.5 mM) ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f48f3d0af05389eb9c003c45becdb9d
https://doi.org/10.1055/s-0038-1650561

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Platelet Accumulation on Fibrin-coated Polyethylene: Role of Platelet Activation and Factor XIII

Autor: P. D. Bishop, Marian A. Packham, D W Perry, Mark W.C. Hatton, Fraser D. Rubens, Raelene L. Kinlough-Rathbone

Publikováno v: Thrombosis and Haemostasis. 73:850-856

SummaryPlatelet accumulation on small- and medium-calibre vascular grafts plays a significant role in graft occlusion. We examined platelet accumulation on the surface of fibrin-coated polyethylene tubing (internal diameter 0.17 cm) during 10 min of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35c9e8fc2da0985f0a89c4be6805454e
https://doi.org/10.1055/s-0038-1653880

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Prolonged Expression of Procoagulant Activity of Human Platelets Degranulated by Thrombin

Autor: D W Perry, Raelene L. Kinlough-Rathbone

Publikováno v: Thrombosis and Haemostasis. 74:958-961

SummaryPlatelets are exposed to thrombin when they take part in arterial thrombus formation, and they may return to the circulation when they are freed by fibrinolysis and dislodged by flowing blood. Thrombin causes the expression of procoagulant act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b06c327493f0b1ca057ef4ce42760a1
https://doi.org/10.1055/s-0038-1649855

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Contrasting Effects of Thrombin and the Thrombin Receptor Peptide, SFLLRN, on Aggregation and Release of 14C-Serotonin by Human Platelets Pretreated with Chymotrypsin or Serratia marcescens Protease

Autor: Raelene L. Kinlough-Rathbone, Marian A. Packham, D W Perry

Publikováno v: Thrombosis and Haemostasis. 73:122-125

SummaryChymotrypsin cleaves glycoprotein Ib (GPIb) on platelets and reduces their responsiveness to thrombin; platelets from patients with the Bernard-Soulier syndrome, which lack GPIb, are also less responsive to thrombin than platelets from normal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b8e8313fb6896052f26492c4188c458
https://doi.org/10.1055/s-0038-1653736

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Degranulation of Human Platelets by the Thrombin Receptor Peptide SFLLRN: Comparison with Degranulation by Thrombin

Autor: Marian A. Packham, D W Perry, Margaret L. Rand, Raelene L. Kinlough-Rathbone, MA Guccione

Publikováno v: Thrombosis and Haemostasis. 70:1019-1023

SummaryA new, simplified method of degranulating human platelets using the thrombin receptor peptide SFLLRN (20 |iM) is described; released fibrinogen cannot be converted to fibrin, and the platelets are not exposed to a proteolytic enzyme, as they a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c30132c114c1188f878587a2c36dc17
https://doi.org/10.1055/s-0038-1649718

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Rabbit lung macrophages stimulate platelets in vitro as observed by density-gradient centrifugation and transmission electron microscopy

Autor: Raelene L. Kinlough-Rathbone, L. Jørgensen, D W Perry, J F Mustard, G. J. Nilsen

Publikováno v: Scandinavian Journal of Clinical and Laboratory Investigation. 53:711-724

Both platelets and macrophages play a role in the pathogenesis of atherosclerosis. To examine whether they may interact and, if they do, to elucidate the mechanisms of such an interaction, suspensions of the two cell types from rabbits were mixed tog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf900d369a28720e09f933ba6a89ce9
https://doi.org/10.3109/00365519309092576

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