Výsledky vyhledávání - "D W, Moreland"

Identification and characterization of m1 selective muscarinic receptor antagonists1

Autor: C E, Augelli-Szafran, C J, Blankley, J C, Jaen, D W, Moreland, C B, Nelson, J R, Penvose-Yi, R D, Schwarz, A J, Thomas

Publikováno v: Journal of medicinal chemistry. 42(3)

A series of esters of 1,4-disubstituted tetrahydropyridine carboxylic acids (I) has been synthesized and characterized as potential m1 selective muscarinic receptor antagonists. The affinity of these compounds for the five human muscarinic receptor s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::850ebb7459e6753d483687aa54d7754c
https://pubmed.ncbi.nlm.nih.gov/9986705

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Discovery of selective, small-molecule inhibitors of RNA complexes--I. The Tat protein/TAR RNA complexes required for HIV-1 transcription

Autor: H Y, Mei, D P, Mack, A A, Galan, N S, Halim, A, Heldsinger, J A, Loo, D W, Moreland, K A, Sannes-Lowery, L, Sharmeen, H N, Truong, A W, Czarnik

Publikováno v: Bioorganicmedicinal chemistry. 5(6)

We have developed a therapeutic program focusing on the inhibition of a human immunodeficiency virus-1 specific protein-RNA interaction. This program begins with a search for small organic molecules that would interfere with the binding of Tat protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::44ced896f35a95030f8637dffade5456
https://pubmed.ncbi.nlm.nih.gov/9222511

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