Výsledky vyhledávání

Molecular modification of a recombinant anti-CD3epsilon-directed immunotoxin by inducing terminal cysteine bridging enhances anti-GVHD efficacy and reduces organ toxicity in a lethal murine model

Autor: D A, Vallera, D W, Kuroki, A, Panoskaltsis-Mortari, D J, Buchsbaum, B E, Rogers, B R, Blazar

Publikováno v: Blood. 96(3)

Immunotoxin (IT) therapy shows potential for selectively eliminating GVHD-causing T cells in vivo, but the field has been hampered by toxicity. Previously, we showed that a genetically engineered IT consisting of a single-chain protein, including the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::93db98e926c30eb88475b67841541283
https://pubmed.ncbi.nlm.nih.gov/10910937

Zobrazit plný text záznamu

Activation of stress-activator protein kinase/c-Jun N-terminal kinase by the non-TPA-type tumor promoter palytoxin

Autor: D W, Kuroki, G S, Bignami, E V, Wattenberg

Publikováno v: Cancer research. 56(3)

Previous studies have shown that structurally diverse tumor promoters can modulate protein kinases involved in signal transduction. In this study, we show that palytoxin, a potent non-12-O-tetradecanoylphorbol-13-acetate (TPA)-type skin tumor promote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::14ea2e92045bfad2e90561c00506666b
https://pubmed.ncbi.nlm.nih.gov/8564984

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání