Zobrazeno 1 - 10
of 11
pro vyhledávání: '"D W, Alberts"'
Publikováno v:
Free Radical Research Communications. 17:263-269
Our previous studies showed that exposure of rats to limited periods of cigarette smoke resulted in more severe myocardial damage when their hearts were subjected to myocardial ischaemia/reperfusion. The aim of this study was to determine whether sup
Publikováno v:
Basic Research in Cardiology. 87:393-399
It is suggested that passive smoking or smoke-exposure increase the risk of coronary heart disease. The same mechanisms as active smoking might play a role. The aim of this study was to determine whether exposure to smoke aggravated ischaemia/reperfu
Publikováno v:
Free Radical Research Communications. 15:151-157
Anaesthetic drugs can induce reversible as well as irreversible changes in cell membranes and intracellular proteins as well as lipid peroxidation in the liver. Low molecular weight iron species (LMWI) can by their catalytic activity contribute to th
Publikováno v:
Journal of the South African Veterinary Association. 67(1)
Several experimental effects due to wood-derived bedding have been reported. Female Sprague Dawley rats were kept on pine shavings, eucalyptus pulp, vermiculite and in wire-bottomed cages without bedding for 14 days whereafter normal values for the a
Publikováno v:
Research communications in molecular pathology and pharmacology. 85(1)
This study was undertaken to investigate whether prior antioxidant supplementation had a beneficial effect on subsequent myocardial ischemic/reperfusion injury and whether addition of ascorbate during ischemia/reperfusion had any effect. Supplementat
Autor:
S J, Grossman, E G, Herold, J M, Drey, D W, Alberts, D R, Umbenhauer, D H, Patrick, D, Nicoll-Griffith, N, Chauret, J A, Yergey
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 21(6)
It has previously been shown that Verlukast is converted to Verlukast dihydrodiol in microsomes from beta-naphthoflavone (BNF)-treated, but not uninduced Swiss Webster mice and Sprague-Dawley rats. We have examined the involvement of CYP1A1 in this r
Publikováno v:
Basic research in cardiology. 87(1)
Reperfusion of ischaemic myocardium is necessary to sustain tissue viability (without it the tissue becomes necrotic), but reperfusion, on the other hand, can damage cells which have survived ischaemia. There is now considerable evidence that oxygen
Autor:
G D, Hoke, F L, McCabe, L F, Faucette, J O, Bartus, C M, Sung, B D, Jensen, J R, Heys, G F, Rush, D W, Alberts, R K, Johnson
Publikováno v:
Molecular pharmacology. 39(1)
Bis(diphenylphosphine)ethane (DPPE) and its gold coordination complexes have demonstrated antitumor activity in transplantable tumor models. This report describes the development of a P388 cell line (P388/DPPEc) that is resistant to DPPE and its anal
Autor:
G F, Rush, P F, Smith, D W, Alberts, C K, Mirabelli, R M, Snyder, S T, Crooke, J, Sowinski, H B, Jones, P J, Bugelski
Publikováno v:
Toxicology and applied pharmacology. 90(3)
Triethylphosphine gold complexes are effective therapeutic agents used for the treatment of rheumatoid arthritis. Many of those molecules are also highly cytotoxic in vitro and can inhibit DNA and protein synthesis. Preliminary experiments have indic
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 249(3)
SKF 104524 (bis-[1,2 bis(diphenylphosphino)-ethane]gold(l) lactate) [( Au(dppe)2]+) is an experimental antineoplastic agent that is hepatotoxic in vivo in the dog as well as highly cytotoxic to isolated canine hepatocytes in vitro. Preliminary studie