Výsledky vyhledávání - "D V, Nazareno"

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist

Autor: J R, Tagat, R W, Steensma, S W, McCombie, D V, Nazareno, S I, Lin, B R, Neustadt, K, Cox, S, Xu, L, Wojcik, M G, Murray, N, Vantuno, B M, Baroudy, J M, Strizki

Publikováno v: Journal of medicinal chemistry. 44(21)

Truncation of the original piperidino-2(S)-methyl piperazine lead structure 2, from a family of muscarinic antagonists, gave compound 8 which has improved selectivity for the HIV-1 co-receptor CCR5 over muscarinic receptors. Further optimization for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4525057c96c5a287b6aa0040fe6af55a
https://pubmed.ncbi.nlm.nih.gov/11585438

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