Zobrazeno 1 - 10
of 50
pro vyhledávání: '"D V, Goeddel"'
Autor:
G H Wong, D V Goeddel
Publikováno v:
The Journal of Immunology. 152:1751-1755
The Fas Ag and the p55 TNF receptor (TNF-R1) are related molecules that can signal apoptosis. Some tumor cell lines are selectively killed by Fas activation and others by TNF-R1 activation even though both receptors are often co-expressed. TNF-R1-med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89a772378fcad8cb9fe90fed50126f94
https://doi.org/10.4049/jimmunol.152.4.1751
https://doi.org/10.4049/jimmunol.152.4.1751
Publikováno v:
The Journal of Immunology. 151:4637-4641
TNF-alpha can enhance the proliferation of human thymocytes stimulated by the comitogen Con A. To determine which of the two different TNF receptors is responsible for signaling this cellular response, we investigated the proliferation of human thymo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18fc0bf6b127980b68aa49374b8ea9cb
https://doi.org/10.4049/jimmunol.151.9.4637
https://doi.org/10.4049/jimmunol.151.9.4637
Publikováno v:
The Journal of Immunology. 149:3350-3353
Agonist antibodies (Ab) to the two TNF receptors, TNF-R1 (55 kDa) and TNF-R2 (75 kDa), have been shown to signal many of the distinct functions induced by TNF-alpha. We have found that anti-TNF-R1, but not anti-TNF-R2, Ab trigger antiviral activity i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80224d20a734df57f0d7d55e93880add
https://doi.org/10.4049/jimmunol.149.10.3350
https://doi.org/10.4049/jimmunol.149.10.3350
Autor:
D V Goeddel, K J Koller
Publikováno v:
Circulation. 86:1081-1088
After the description in the past 5 years of BNP and CNP, interest in the natriuretic peptide family has dramatically increased. Molecular characterization of the receptors for this hormone family has identified a heterogeneity in the receptor subtyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3129ff7b0e89353c1b372ccf086911c
https://doi.org/10.1161/01.cir.86.4.1081
https://doi.org/10.1161/01.cir.86.4.1081
Publikováno v:
Molecular and Cellular Biology. 12:2581-2590
The natriuretic peptide receptors, NPR-A and NPR-B, are two members of the newly described class of receptor guanylyl cyclases. The kinaselike domain of these proteins is an important regulator of the guanylyl cyclase activity. To begin to understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::402a56303a61674950ad9f7782376a86
https://doi.org/10.1128/mcb.12.6.2581
https://doi.org/10.1128/mcb.12.6.2581
Publikováno v:
Molecular and Cellular Biology. 11:5860-5866
At least two species-specific gene products are required for signal transduction by interferon gamma (IFN-gamma). The first is the IFN-gamma receptor, which binds ligand with high affinity in a species-specific manner. The second is an undetermined s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::088b7ac0ed686b9a880015b37068d7be
https://doi.org/10.1128/mcb.11.12.5860
https://doi.org/10.1128/mcb.11.12.5860
Autor:
A. ROSENTHAL, D. V. GOEDDEL, T. NGUYEN, E. MARTIN, L. E. BURTON, A. SHIH, G. R. LARAMEE, F. WURM, A. MASON, K. NIKOLICS, J. W. WINSLOW
Publikováno v:
Endocrinology. 129:1289-1294
Brain-derived neurotrophic factor (BDNF) is a 27-kDa basic protein of noncovalently linked 13.5-kD subunits related to nerve growth factor and is produced by the central nervous system (CNS). BDNF has been shown to promote the survival of neurons loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9508e51d77d1d8cd9e912e5740858d0
https://doi.org/10.1210/endo-129-3-1289
https://doi.org/10.1210/endo-129-3-1289
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 95(7)
Activation of the transcription factor NF-kappaB by inflammatory cytokines involves the successive action of NF-kappaB-inducing kinase (NIK) and two IkappaB kinases, IKK-alpha and IKK-beta. Here we show that NIK preferentially phosphorylates IKK-alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9349a755115bf688103548cd0b87247
https://pubmed.ncbi.nlm.nih.gov/9520446
https://pubmed.ncbi.nlm.nih.gov/9520446
Autor:
D V, Goeddel
Publikováno v:
Harvey lectures. 92
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2533544ee513874d0f0aee8314fa69f4
https://pubmed.ncbi.nlm.nih.gov/15372742
https://pubmed.ncbi.nlm.nih.gov/15372742
Autor:
L. P. Dehner, J. K. Pinckard, Cora D. Arthur, D. V. Goeddel, Kathleen C. F. Sheehan, Robert D. Schreiber
Publikováno v:
The Journal of Experimental Medicine
Monoclonal antibodies (mAbs) specific for the murine p55 and p75 tumor necrosis factor (TNF) receptors were produced after immunization of Armenian hamsters with the purified soluble extracellular domains of each receptor protein. Four p55- (55R) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba926588724e1d21b249c38bf942a873
https://pubmed.ncbi.nlm.nih.gov/7836916
https://pubmed.ncbi.nlm.nih.gov/7836916