Zobrazeno 1 - 10
of 1 661
pro vyhledávání: '"D Ulrich"'
Autor:
Lonnie P. Swift, B. Christoffer Lagerholm, Lucy R. Henderson, Malitha Ratnaweera, Hannah T. Baddock, Blanka Sengerova, Sook Lee, Abimael Cruz-Migoni, Dominic Waithe, Christian Renz, Helle D. Ulrich, Joseph A. Newman, Christopher J. Schofield, Peter J. McHugh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract DNA double-strand breaks (DSBs), such as those produced by radiation and radiomimetics, are amongst the most toxic forms of cellular damage, in part because they involve extensive oxidative modifications at the break termini. Prior to comple
Externí odkaz:
https://doaj.org/article/cd10c307980d47f8a16e6289838eff95
Autor:
Kook Son, Vakil Takhaveev, Visesato Mor, Hobin Yu, Emma Dillier, Nicola Zilio, Nikolai J. L. Püllen, Dmitri Ivanov, Helle D. Ulrich, Shana J. Sturla, Orlando D. Schärer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Most genotoxic anticancer agents fail in tumors with intact DNA repair. Therefore, trabectedin, anagent more toxic to cells with active DNA repair, specifically transcription-coupled nucleotide excision repair (TC-NER), provides therapeutic
Externí odkaz:
https://doaj.org/article/1a45c02a032c494596a84c053a37fd46
Autor:
Yucui Chen, Shangming Liu, Ariel A. Jacobi, Grace Jeng, Jason D. Ulrich, Ivar S. Stein, Tommaso Patriarchi, Johannes W. Hell
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 16 (2024)
Rapid, synapse-specific neurotransmission requires the precise alignment of presynaptic neurotransmitter release and postsynaptic receptors. How postsynaptic glutamate receptor accumulation is induced during maturation is not well understood. We find
Externí odkaz:
https://doaj.org/article/6d7dffd05015408a8a2becc1cdb91599
Autor:
Jie Shi, Kristine Hauschulte, Ivan Mikicic, Srijana Maharjan, Valerie Arz, Tina Strauch, Jan B. Heidelberger, Jonas V. Schaefer, Birgit Dreier, Andreas Plückthun, Petra Beli, Helle D. Ulrich, Hans-Peter Wollscheid
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The actin cytoskeleton is of fundamental importance for cellular structure and plasticity. However, abundance and function of filamentous actin in the nucleus are still controversial. Here we show that the actin-based molecular motor myosin
Externí odkaz:
https://doaj.org/article/664388851c7f4b1e93e0bfdb9d7cdc53
Autor:
Olusola A. Omisakin, Jessica D. Ulrich-Schad, Aaron Hunt, Jennifer E. Givens, Mitchell Beacham
Publikováno v:
Preventive Medicine Reports, Vol 36, Iss , Pp 102390- (2023)
Introduction: Since its emergence in December 2019, COVID-19 has caused millions of deaths worldwide. While vaccines are largely available in most places, including the United States (U.S.), vaccine uptake is lower than is desirable from a public hea
Externí odkaz:
https://doaj.org/article/34a0779dd2214d07a1303c1aaf60ec29
Autor:
Hillary S. Weiner, M.B.E., Nicole D. Ulrich, M.D., Lauren Hipp, M.S., C.G.C., Ahmad Hammoud, M.D., Min Xu, Ph.D., Samantha B. Schon, M.D.
Publikováno v:
F&S Reports, Vol 3, Iss 4, Pp 355-360 (2022)
Objective: To report a unique case of total fertilization failure (TFF) after in vitro fertilization with intracytoplasmic sperm injection related to homozygous WEE2 gene mutation and summarize the current literature and management of TFF. Design: Ca
Externí odkaz:
https://doaj.org/article/caef12481ebc47d59852220a7899a768
Autor:
Chanung Wang, Aishwarya Nambiar, Michael R. Strickland, Choonghee Lee, Samira Parhizkar, Alec C. Moore, Erik S. Musiek, Jason D. Ulrich, David M. Holtzman
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 14 (2023)
Alzheimer’s disease (AD) is the most common cause of dementia. The APOE-ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset AD. The APOE genotype modulates the effect of sleep disruption on AD risk, su
Externí odkaz:
https://doaj.org/article/4077923727354c88afb1cf8c8e6f7e7a
Autor:
Nimansha Jain, Jason D. Ulrich
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-3 (2022)
Abstract Tau pathology appears to spread along neuronal networks via the template misfolding of tau by pathological tau conformations. The mechanisms underlying neuron-to-neuron transmission of tau are unclear and recent work demonstrates a role for
Externí odkaz:
https://doaj.org/article/833fc777a5ec45cc9692fdf8d127a00f
Publikováno v:
Women, Vol 2, Iss 2, Pp 115-120 (2022)
Natural disasters and major weather events can have a large impact on fertility treatment in the affected area through unplanned clinic closures leading to cancelled cycles, severe weather endangering cryopreserved embryos and gametes, and long delay
Externí odkaz:
https://doaj.org/article/06d251e7033f4239a7e0e2a0ca5803c7
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-20 (2022)
Abstract Background One of the key pathological hallmarks of Alzheimer disease (AD) is the accumulation of the amyloid-β (Aβ) peptide into amyloid plaques. The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset AD and
Externí odkaz:
https://doaj.org/article/f3a88e4afff14cb6a4fc4d21da89f36f