Zobrazeno 1 - 10
of 182
pro vyhledávání: '"D Twomey"'
Autor:
Julianne D. Twomey, Baolin Zhang
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 934 (2023)
Circulating tumor cells (CTCs) in the peripheral blood are believed to be the source of metastasis and can be used as a liquid biopsy to monitor cancer progression and therapeutic response. However, it has been challenging to accurately detect CTCs b
Externí odkaz:
https://doaj.org/article/cd35433dc7b74a9f9e7e3aadd0e1f180
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Antibody-drug conjugates (ADCs) are a rapidly expanding class of biotherapeutics that utilize antibodies to selectively deliver cytotoxic drugs to the tumor site. As of May 2021, the U.S. Food and Drug Administration (FDA) has approved ten ADCs, name
Externí odkaz:
https://doaj.org/article/0ea1fe9accbc4cd4ace5cfd15f8eba42
Autor:
Alexis Q Dean, Charles B Stauft, Julianne D Twomey, Joshua Tan, Luca Varani, Tony T Wang, Baolin Zhang
Publikováno v:
Antibody Therapeutics. 6:49-58
BackgroundNeutralising antibodies against SARS-CoV-2 are a vital component in the fight against COVID-19 pandemic, having the potential of both therapeutic and prophylactic applications. Bispecific antibodies (BsAbs) against SARS-CoV-2 are particular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f01d08c6b9049917eaffbba29faf9bc2
https://doi.org/10.1093/abt/tbac032
https://doi.org/10.1093/abt/tbac032
Publikováno v:
Cancer Metastasis Reviews
The presence of circulating tumor cells (CTCs) in the bloodstream signals the existence of a tumor and denotes risk of metastatic spread. CTCs can be isolated and analyzed to monitor cancer progression and therapeutic response. However, CTC isolation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209384cac3c0a927e30e7039e0e22891
https://doi.org/10.1007/s10555-019-09795-4
https://doi.org/10.1007/s10555-019-09795-4
Publikováno v:
Oncotarget
Activation of death receptor 5 (DR5) to induce apoptosis in cancer cells is an attractive strategy for cancer therapy. However, many tumor cell lines and primary tumors are resistant to DR5 targeted agents including recombinant tumor necrosis factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e4c61e62b5313baad40a275bbd92fa
https://doi.org/10.18632/oncotarget.26407
https://doi.org/10.18632/oncotarget.26407
Publikováno v:
Drug Discovery Today
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters host cells by interacting with membrane-bound angiotensin-converting enzyme 2 (ACE2), a vital element in the renin-angiotensin system (RAS), which regulates blood pressure,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36d0a5d240d9e6576289b638c109dea
http://europepmc.org/articles/PMC8049177
http://europepmc.org/articles/PMC8049177
Autor:
Baolin Zhang, Julianne D. Twomey
Publikováno v:
The AAPS Journal
Immune checkpoint inhibitors (ICIs) are considered a new standard-of-care across many cancer indications. This review provides an update on ICIs approved by the Food and Drug Administration (FDA), with focus on monoclonal antibodies that target the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d7d2c226b14d8867fdfac3e2f63d12
https://pubmed.ncbi.nlm.nih.gov/33677681
https://pubmed.ncbi.nlm.nih.gov/33677681
Autor:
Conal D Twomey
Publikováno v:
Journal of Epidemiology and Community Health. 71:811-816
Background The directionality and magnitude of the association of cannabis use with elevated anxiety symptoms in the general population is unclear. The aim of this meta-analysis was to investigate the association of cannabis use with the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d3baacffde6afd7f65dff28a331eb3
https://doi.org/10.1136/jech-2016-208145
https://doi.org/10.1136/jech-2016-208145
Publikováno v:
Drug Resistance Updates. 30:48-62
Predictive biomarkers for oncology are necessary to accurately identify patients who will benefit from anticancer treatment. Recently approved oncology drugs target discrete molecular aberrations or pathways in tumor cells and consequently are active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f18b6253bf86f216ae4f51dee607f1
https://doi.org/10.1016/j.drup.2017.02.002
https://doi.org/10.1016/j.drup.2017.02.002
Autor:
T. Agbaedeng, Shivshankar Thanigaimani, P. Sanders, Dennis H. Lau, D. Twomey, Rajiv Mahajan, Dominik Linz
Publikováno v:
European Heart Journal. 40
Background Obesity-mediated epicardial adipose tissue (EAT) expansion drives fat cell infiltration which forms the unique substrate for atrial fibrillation (AF). The LEGACY study showed the benefits of weight loss but an attenuated response with weig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b01c4fe49fbed6a884b70e2ec956b17
https://doi.org/10.1093/eurheartj/ehz748.0192
https://doi.org/10.1093/eurheartj/ehz748.0192