A leucine‐rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls

Autor: Maurits F. J. M. Vissers, Matthew D. Troyer, Eva Thijssen, Diana R. Pereira, Jules A. A. C. Heuberger, Geert Jan Groeneveld, Sarah Huntwork‐Rodriguez

Publikováno v: Clinical and Translational Science, Vol 16, Iss 8, Pp 1408-1420 (2023)

Abstract Increased leucine‐rich repeat kinase 2 (LRRK2) kinase activity is an established risk factor for Parkinson's disease (PD), and several LRRK2 kinase inhibitors are in clinical development as potential novel disease‐modifying therapeutics.

Externí odkaz: https://doaj.org/article/1457c080406e4c51abbd0acec3fd46d1

Safety, Tolerability, and Pharmacokinetics of the β‐Site Amyloid Precursor Protein‐Cleaving Enzyme 1 Inhibitor Verubecestat (MK‐8931) in Healthy Elderly Male and Female Subjects

Autor: Mark Forman, John Palcza, Jack Tseng, Julie A. Stone, Brittany Walker, Dennis Swearingen, Matthew D. Troyer, Marissa F. Dockendorf

Publikováno v: Clinical and Translational Science, Vol 12, Iss 5, Pp 545-555 (2019)

β‐site amyloid precursor protein‐cleaving enzyme 1 (BACE1) is required for the production of β‐amyloid peptides, which are implicated in the etiology of Alzheimer's disease. The safety and pharmacokinetics of the BACE1 inhibitor verubecestat

Externí odkaz: https://doaj.org/article/d5a82e2a471d464587738eee563b31d1

Ultrasound‐guided injection of the long head of the biceps tendon sheath with concomitant subacromial bursa injection through the same needlestick

Autor: George Pujalte, Loren J. Hudspeth, Wesley D. Troyer, Shane A. Shapiro

Publikováno v: Clinical Anatomy. 36:400-405

Sonography and specific shoulder positions allow for injections into both the long head of the biceps tendon sheath (LHBTS) and the subacromial space (SS) with one needlestick. We validated this technique using cadavers. An experienced proceduralist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9585d0f9ed3faf12660efa05a1edbf87
https://doi.org/10.1002/ca.23961

The NCI Genomic Data Commons

Autor: Raymond Powell, Phuong-My Do, Mark A. Jensen, Tanja Davidsen, Michael S. Fitzsimons, Karl Rademacher, Daniel P. Miller, Ariz Zubair, Christina K. Yung, Francisco M. Ortuño, Stuti Agrawal, Allison Heath, James C. Angelakos, Kim Cullion, Shenglai Li, Yajing Tang, Janice Lodato, Martin L. Ferguson, Gajanan Ganji, Liming Yang, Kang Han, Sid Joshi, Jesús Pedrosa, Lincoln Stein, Zhining Wang, Jeffrey A. Mazzone, Plamen Martinov, Bessie Rogel, Alex Wilmer, Yuanheng Zhao, Vincent Ferretti, Mathangi Thiagarajan, Zhenyu Zhang, Francois Gerthoffert, Koji Miyauchi, Christian Dompierre, Jonathan Spring, Kaman Wu, Laxmi Lolla, Kyle M. Hernandez, Heather D. Troyer, Ian J. Miller, William P. Wysocki, Joseph Sislow, Linda Xiang, Mark W. Murphy, Joshua S. Miller, Jeffrey Burt, James J. Porter, Shane Wilson, Maksim An, Robert L. Grossman, Sean Sullivan, Bilal Baqar, Renuka Arya, Joseph Tadashi Yamada, Daniela S. Gerhard, Miyuki Fukuma, Maxim Y. Popov, Rosita Bajari, Thomas Nullet, Tara M. Lichtenberg, Jeremiah Savage, Tzintzuni Garcia, Fauzi Gomez, Samantha Rich, Louis M. Staudt, Bedford L. West, Ajinkya Kadam, Kyle A. Schmitt, Phuong L. Pham, Richard Jackson, Michael Ford, Sharon Gaheen, Himanso Sahni, Rowland O. Ogwara, Chang Wang, Victoria E. Kraft, Aishmit Khurana, Sameera S. George, Fay Chu, Colin P. Reid, Christine Yu, Jean C. Zenklusen, Ann Catton, Biju Issac, Justin H. B. Barnowski, Kyle M. J. Kim, Brandon F. Chan, Trevar J. Simmons, Junjun Zhang

Publikováno v: Nature Genetics. 53:257-262

The National Cancer Institute (NCI) Genomic Data Commons (GDC) contains more than 2.9 petabytes of genomic and associated clinical data from more than 60 NCI-funded and other contributed cancer genomics research projects. The GDC consists of five app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::124e4ec3f026af38432b7b0b860726f4
https://doi.org/10.1038/s41588-021-00791-5

Molecular architecture determines brain delivery of a transferrin receptor–targeted lysosomal enzyme

Autor: Annie Arguello, Cathal S. Mahon, Meredith E.K. Calvert, Darren Chan, Jason C. Dugas, Michelle E. Pizzo, Elliot R. Thomsen, Roni Chau, Lorna A. Damo, Joseph Duque, Meng Fang, Tina Giese, Do Jin Kim, Nicholas Liang, Hoang N. Nguyen, Hilda Solanoy, Buyankhishig Tsogtbaatar, Julie C. Ullman, Junhua Wang, Mark S. Dennis, Dolores Diaz, Kannan Gunasekaran, Kirk R. Henne, Joseph W. Lewcock, Pascal E. Sanchez, Matthew D. Troyer, Jeffrey M. Harris, Kimberly Scearce-Levie, Lu Shan, Ryan J. Watts, Robert G. Thorne, Anastasia G. Henry, Mihalis S. Kariolis

Publikováno v: Journal of Experimental Medicine. 219

Delivery of biotherapeutics across the blood–brain barrier (BBB) is a challenge. Many approaches fuse biotherapeutics to platforms that bind the transferrin receptor (TfR), a brain endothelial cell target, to facilitate receptor-mediated transcytos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f8502d8d835baeb28ac3730bfbbf0e
https://doi.org/10.1084/jem.20211057