Výsledky vyhledávání - "D T Fleischer"

Inherited human complement C5 deficiency. Nonsense mutations in exons 1 (Gln1 to Stop) and 36 (Arg1458 to Stop) and compound heterozygosity in three African-American families

Autor: X Wang, D T Fleischer, W T Whitehead, D L Haviland, S I Rosenfeld, J P Leddy, R Snyderman, R A Wetsel

Publikováno v: The Journal of Immunology. 154:5464-5471

Hereditary C5 deficiency has been reported in several families of different ethnic backgrounds and from different geographic regions, but the molecular genetic defect causing C5 deficiency has not been delineated in any of them. To examine the molecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::053922c2454abcd47457bf1fbebcd53b
https://doi.org/10.4049/jimmunol.154.10.5464

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Complete cDNA sequence of human complement pro-C5. Evidence of truncated transcripts derived from a single copy gene

Autor: D L Haviland, J C Haviland, D T Fleischer, A Hunt, R A Wetsel

Publikováno v: The Journal of Immunology. 146:362-368

Two truncated human C5 clones, pHC5A and pHC5B, were isolated from an adult human liver cDNA library, and contained inserts of 2930 and 2181 bp, respectively. Both clones were polyadenylated and encoded the 5'-end of the C5 pro-molecule, thereby comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2f4cee2a24c77bc76430ef8292b4e1a
https://doi.org/10.4049/jimmunol.146.1.362

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Inherited human complement C5 deficiency. Nonsense mutations in exons 1 (Gln1 to Stop) and 36 (Arg1458 to Stop) and compound heterozygosity in three African-American families

Autor: X, Wang, D T, Fleischer, W T, Whitehead, D L, Haviland, S I, Rosenfeld, J P, Leddy, R, Snyderman, R A, Wetsel

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 154(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2a16e57652b556fde8f98fb6ebaace77
https://pubmed.ncbi.nlm.nih.gov/7730648

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Structure of the murine fifth complement component (C5) gene. A large, highly interrupted gene with a variant donor splice site and organizational homology with the third and fourth complement component genes

Autor: D L, Haviland, J C, Haviland, D T, Fleischer, R A, Wetsel

Publikováno v: The Journal of biological chemistry. 266(18)

To understand fifth complement component (C5) gene regulation, splicing, and C5 protein deficiency at the molecular level, the organization of the murine C5 gene was determined. The C5 structural gene is present as a single copy in the mouse genome a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f6a4d2c3fbd751fa9d3aa0ac758c9c6a
https://pubmed.ncbi.nlm.nih.gov/1711041

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Complete cDNA sequence of human complement pro-C5. Evidence of truncated transcripts derived from a single copy gene

Autor: D L, Haviland, J C, Haviland, D T, Fleischer, A, Hunt, R A, Wetsel

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 146(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e608e4c07afc61cb686a3f07bde62184
https://pubmed.ncbi.nlm.nih.gov/1984448

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Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5'-exon

Autor: R A, Wetsel, D T, Fleischer, D L, Haviland

Publikováno v: The Journal of biological chemistry. 265(5)

To ascertain the molecular mechanism that causes murine C5 deficiency, genomic and cDNA libraries were constructed from mouse liver DNA and mRNA employing the congenic strains B10.D2/nSnJ and B10.D2/oSnJ that are sufficient and deficient for C5, resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb9e6b4a4c19df7f5623dc3dc4d9d488
https://pubmed.ncbi.nlm.nih.gov/2303408

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