Zobrazeno 1 - 10 of 24 pro vyhledávání: '"D T, Vistica"'
1
Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism
Autor: M I, Rivera, S F, Stinson, D T, Vistica, J L, Jorden, S, Kenney, E A, Sausville
Publikováno v: Biochemical pharmacology. 57(11)
The tricyclic compound 2,5-bis(5-hydroxymethyl-2-thienyl)furan (NSC 652287) has shown a highly selective pattern of differential cytotoxic activity in the tumor cell lines comprising the National Cancer Institute (NCI) Anticancer Drug Screen. The mec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2db5271a4b17c156b6efdafd96402aa4
https://pubmed.ncbi.nlm.nih.gov/10230772
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2
Histological, histochemical and autoradiographic evidence of in vitro neurotoxic effects of the novel antitumor agent, 9-methoxy-N2-methylellipticinium acetate
Autor: L, Shankar, V, Ravindranath, M R, Boyd, D T, Vistica, S K, Shankar
Publikováno v: Neurotoxicology. 18(1)
9-Methoxy-N2-methylellipticinium acetate (MMEA) exhibits selective cytotoxicity towards glial-derived human brain tumor cell lines comprising the U.S. National Cancer Institute preclinical drug screen. Neurotoxic potential of MMEA has been demonstrat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c76b8752e1c051de9f0f7e7ce59feee0
https://pubmed.ncbi.nlm.nih.gov/9215991
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3
Role of membrane potential in the accumulation of quaternized ellipticines by human tumor cell lines
Autor: D T, Vistica, S, Kenney, M, Hursey, M R, Boyd
Publikováno v: The Journal of pharmacology and experimental therapeutics. 279(2)
9-Methoxy-N2-methylellipticinium acetate (MMEA) is representative of a series of quaternized ellipticines that exhibited selective cytotoxicity for human brain tumor cell lines of glial origin in the in vitro primary screen of the U.S. National Cance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e864826851f68b4399d09637cf400df1
https://pubmed.ncbi.nlm.nih.gov/8930212
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4
Rapid high-affinity transport of a chemotherapeutic amino acid across the blood-brain barrier
Autor: Y, Takada, D T, Vistica, N H, Greig, D, Purdon, S I, Rapoport, Q R, Smith
Publikováno v: Cancer research. 52(8)
The therapeutic efficacy of many anticancer drugs against intracerebral tumors is limited by poor uptake into the central nervous system. One way to enhance brain delivery is to design agents that are transported into the brain by the saturable nutri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5abcbfb2e55add9f72596dd7cfe61077
https://pubmed.ncbi.nlm.nih.gov/1559223
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5
Tetrazolium-based assays for cellular viability: a critical examination of selected parameters affecting formazan production
Autor: D T, Vistica, P, Skehan, D, Scudiero, A, Monks, A, Pittman, M R, Boyd
Publikováno v: Cancer research. 51(10)
The hydrogen acceptor 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) is commonly utilized to estimate cellular viability in drug screening protocols. The present investigation was prompted, in part, by observations that reduction
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f1853d336fc76a1d99a2d2e7827fcec
https://pubmed.ncbi.nlm.nih.gov/2021931
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6
Elevation of glutathione in phenylalanine mustard-resistant murine L1210 leukemia cells
Autor: B Le, P Najarian, S Ahmad, L Okine, D T Vistica
Publikováno v: Journal of Biological Chemistry. 262:15048-15053
Murine L1210 leukemia cells resistant to the antineoplastic agent L-phenylalanine mustard have a 1.5-2.0-fold elevation in their cellular GSH and GSSG content as compared to drug-sensitive cells. Cellular uptake of L-[U-14C]cystine and its incorporat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d88cc6fd72f33c48fd0d7056f119288
https://doi.org/10.1016/s0021-9258(18)48136-7
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7
Cytotoxicity as an indicator for transport mechanism: evidence that murine bone marrow progenitor cells lack a high-affinity leucine carrier that transports melphalan in murine L1210 leukemia cells
Autor: D T, Vistica
Publikováno v: Blood. 56:427-429
Cytotoxicity of melphalan to murine L1210 leukemia cells was reduced to a limiting maximum value of 50% by 2-aminobicyclo[2,2,1]heptane-2- carboxylic acid (BCH), indicating that cytotoxicity is partially dependent on drug uptake by system L. L-Leucin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59531c3a3c5aa18d964ffb4d44789f74
https://doi.org/10.1182/blood.v56.3.427.bloodjournal563427
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9
Mechanisms of sensitivity or resistance of murine tumors to N-(phosphonacetyl)-L-aspartate (PALA)
Autor: H N, Jayaram, D A, Cooney, D T, Vistica, S, Kariya, R K, Johnson
Publikováno v: Cancer treatment reports. 63(8)
Several biochemical parameters were examined relative to the sensitivity or resistance of representative rodent tumors to N-(phosphonacetyl)-L-aspartate (PALA). The activity of the target enzyme, L-aspartate transcarbamylase (ATCase), was evaluated i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69859d93fa4b02c672c00872ad0a1346
https://pubmed.ncbi.nlm.nih.gov/476706
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