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Akademický článek

Local energetic frustration conservation in protein families and superfamilies

Autor: Maria I. Freiberger, Victoria Ruiz-Serra, Camila Pontes, Miguel Romero-Durana, Pablo Galaz-Davison, Cesar A. Ramírez-Sarmiento, Claudio D. Schuster, Marcelo A. Marti, Peter G. Wolynes, Diego U. Ferreiro, R. Gonzalo Parra, Alfonso Valencia

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract Energetic local frustration offers a biophysical perspective to interpret the effects of sequence variability on protein families. Here we present a methodology to analyze local frustration patterns within protein families and superfamilies

Externí odkaz: https://doaj.org/article/8a24deca089846af8b9e2382e5a27117

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Akademický článek

Human adipose-derived stromal/stem cells expressing doublecortin improve cartilage repair in rabbits and monkeys

Autor: Dongxia Ge, Michael J. O’Brien, Felix H. Savoie, Jeffrey M. Gimble, Xiying Wu, Margaret H. Gilbert, Gabrielle L. Clark-Patterson, Jason D. Schuster, Kristin S. Miller, Alun Wang, Leann Myers, Zongbing You

Publikováno v: npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-16 (2021)

Abstract Localized cartilage lesions in early osteoarthritis and acute joint injuries are usually treated surgically to restore function and relieve pain. However, a persistent clinical challenge remains in how to repair the cartilage lesions. We exp

Externí odkaz: https://doaj.org/article/817693d80fe147a099eeab83664e6183

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Akademický článek

Structural modeling of a novel membrane-bound globin-coupled sensor in Geobacter sulfurreducens

Autor: Dietmar Hammerschmid, Francesca Germani, Salvador I. Drusin, Charline Fagnen, Claudio D. Schuster, David Hoogewijs, Marcelo A. Marti, Catherine Venien-Bryan, Luc Moens, Sabine Van Doorslaer, Frank Sobott, Sylvia Dewilde

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 1874-1888 (2021)

Globin-coupled sensors (GCS) usually consist of three domains: a sensor/globin, a linker, and a transmitter domain. The globin domain (GD), activated by ligand binding and/or redox change, induces an intramolecular signal transduction resulting in a

Externí odkaz: https://doaj.org/article/02c5fe5a57b54d7b85a3d980154a4e0b

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Akademický článek

Type 1 Insulin-Like Growth Factor Receptor Nuclear Localization in High-Grade Glioma Cells Enhances Motility, Metabolism, and In Vivo Tumorigenesis

Autor: Ayelen Martin, María Celia Fernandez, Elizabeth R. Cattaneo, Claudio D. Schuster, Marcela Venara, Florencia Clément, Ariel Berenstein, Mercedes García Lombardi, Ignacio Bergadá, Mariana Gutierrez, Marcelo A. Martí, María R. Gonzalez-Baro, Patricia A. Pennisi

Publikováno v: Frontiers in Endocrinology, Vol 13 (2022)

Gliomas are the most frequent solid tumors in children. Among these, high-grade gliomas are less common in children than in adults, though they are similar in their aggressive clinical behavior. In adults, glioblastoma is the most lethal tumor of the

Externí odkaz: https://doaj.org/article/7510edb0b18e4e02b18bc3639f25903e

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Akademický článek

Pharmacological and molecular dynamics analyses of differences in inhibitor binding to human and nematode PDE4: Implications for management of parasitic nematodes.

Autor: Kevin D Schuster, Mohammadjavad Mohammadi, Karyn B Cahill, Suzanne L Matte, Alexis D Maillet, Harish Vashisth, Rick H Cote

Publikováno v: PLoS ONE, Vol 14, Iss 3, p e0214554 (2019)

Novel chemical controls are needed that selectively target human, animal, and plant parasitic nematodes with reduced adverse effects on the host or the environment. We hypothesize that the phosphodiesterase (PDE) enzyme family represents a potential

Externí odkaz: https://doaj.org/article/87194c07a26f4842992eb1be6c0087df

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