Zobrazeno 1 - 10
of 21
pro vyhledávání: '"D S Gregerson"'
Publikováno v:
The Journal of Immunology. 146:75-80
Experimental autoimmune uveoretinitis (EAU) is a predominantly T cell-mediated autoimmune disease induced in susceptible animals by active immunization with human or bovine retinal S-Ag or by passive transfer of activated S-Ag or peptide-specific CD4
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(8)
To assess the role of sequestration in the maintenance of the immune privilege of the retina, retrovirally mediated gene transfer was used to express a defined, specific retinal autoantigen, rat soluble retinal Ag (S-Ag), in a systemic, nonsequestere
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(2)
Recent studies revealing active mechanisms of immune privilege in neural tissues have diminished the putative role of passive tolerance. To examine the significance of Ag localization in the retina on immune privilege, the immune responses of transge
Publikováno v:
Investigative ophthalmologyvisual science. 40(1)
To transduce corneal epithelial progenitor cells with a reporter gene using a retroviral vector and follow their progeny in vitro and in vivo.Using a lacZ-producing retroviral vector, rabbit keratolimbal explants were transduced ex vivo, autografted
Publikováno v:
Investigative ophthalmologyvisual science. 39(11)
To design a new model of proliferative vitreoretinopathy (PVR) that would not rely on the addition of exogenous cells. The release of endogenous cells from surrounding attachments seems to be an early event in the pathogenesis of PVR. Because the pro
Autor:
S, Yamagami, H, Kawashima, T, Tsuru, H, Yamagami, N, Kayagaki, H, Yagita, K, Okumura, D S, Gregerson
Publikováno v:
Transplantation. 64(8)
The expression of Fas ligand (FasL) in the eye has been proposed to be an important component of ocular immune privilege. Since the unusually favorable outcome of corneal transplantation is thought to result from the immune privilege of the eye, exam
A new, simple, nonradioactive, nontoxic in vitro assay to monitor corneal endothelial cell viability
Publikováno v:
Investigative ophthalmologyvisual science. 38(10)
This study was designed to determine whether Alamar blue could be used to evaluate corneal endothelial cell viability in vitro.Alamar blue incorporates a proprietary redox indicator that changes color in response to metabolic activity. Primary rabbit
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 153(5)
We have reported that Ia+ LEW rat corneal endothelial (CE) cells could not induce Ag-specific proliferation of MHC compatible T cell lines. Instead, the presence of CE cell monolayers inhibited T cell proliferation assays. We now report on the effect
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 151(10)
Studies of oral tolerance in LEW rat models of autoimmune diseases including S-antigen (S-Ag)-mediated experimental autoimmune uveoretinitis (EAU), and myelin basic protein-induced experimental autoimmune encephalomyelitis have produced conflicting e
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 147(2)
Previous analyses of T cell recognition sites on immunopathogenic neural autoantigens have demonstrated, using LEW rats, the functional dissociation of in vitro proliferative responses and the ability to actively induce autoimmune diseases. In experi