Zobrazeno 1 - 10
of 38
pro vyhledávání: '"D S Friend"'
Publikováno v:
The Journal of Immunology. 158:4373-4380
Mast cells are a heterogeneous family of immune cells that, when activated through their high affinity IgE receptors (Fc epsilonRI), release various granule mediators (e.g., neutral proteases and serglycin proteoglycans) and proinflammatory cytokines
Publikováno v:
Blood. 88:4338-4347
The expression of leukotriene C4 synthase (LTC4S) was examined during the development of eosinophils in vitro from cord blood mononuclear cells. At 7 days, the cells contained mRNA and sodium dodecyl sulfate-polyacrylamide gel electrophoresis immunob
Publikováno v:
The Journal of Immunology. 151:3206-3214
BALB/cJ mouse mast cells derived by culturing bone marrow progenitor cells in WEHI-3 cell-conditioned medium (BMMCW) do not contain mouse mast cell protease 2 (mMCP-2) mRNA, but these cells can be induced to express this transcript after exposure to
Publikováno v:
The Journal of Immunology. 149:2506-2512
In vitro studies suggest that TNF-alpha and IFN-gamma regulate thymocyte proliferation, but little evidence exists for the constitutive production of these cytokines in normal human thymus. In paired experiments, we examined frozen sections of postna
Publikováno v:
Archives of Andrology. 29:33-42
Spermine (Sp) 10(-5) mM had vigorous activity of guinea pig spermatozoa, while it completely abolished sperm forward motility (SFM) at a concentration of 10(-3) mM. There appeared to be a dose relationship to inhibition to motility. 2-Difluoromethylo
Publikováno v:
Biochemical Journal. 275:759-766
To study the organization of fertilization enzymes in the sperm acrosome, we isolated and characterized two physicochemically distinct acrosomal fractions of guinea-pig spermatozoa. A soluble fraction contained the 25,000-Mr acrosomal autoantigen, AA
Autor:
A M, Reimold, A, Etkin, I, Clauss, A, Perkins, D S, Friend, J, Zhang, H F, Horton, A, Scott, S H, Orkin, M C, Byrne, M J, Grusby, L H, Glimcher
Publikováno v:
Genesdevelopment. 14(2)
XBP-1 is a CREB/ATF family transcription factor highly expressed in hepatocellular carcinomas. Here we report that XBP-1 is essential for liver growth. Mice lacking XBP-1 displayed hypoplastic fetal livers, whose reduced hematopoiesis resulted in dea
Autor:
A R, Rosenkranz, A, Coxon, M, Maurer, M F, Gurish, K F, Austen, D S, Friend, S J, Galli, T N, Mayadas
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(12)
Mac-1 (CD11b/CD18, CR3), a beta2 integrin expressed on leukocytes, is important in leukocyte migration. We demonstrate that Mac-1 is also expressed on peritoneal mast cells and LPS stimulated bone marrow-derived cultured mast cells, and that Mac-1-de
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(11)
It is has been established that mouse mast cells (MCs) can reversibly alter their expression of serglycin proteoglycans and the homologous granule chymases that have been designated mouse MC protease (mMCP)-1, mMCP-2, and mMCP-5 in vivo. Nevertheless
Publikováno v:
Blood. 90(1)
Because in humans mast cells and basophils tend to possess nonsegmented and segmented/multi-lobular nuclei, respectively, nuclear morphology has been a major criterion for assessing the lineage of metachromatic cells of hematopoietic origin. Immature