Zobrazeno 1 - 10
of 35
pro vyhledávání: '"D S Cunninghame Graham"'
Publikováno v:
Clinical and Experimental Immunology. 161:284-289
Summary Recent studies have tested genetic variation at the C1QA, C1QB and C1QC (complement component 1, q subcomponent, A chain, complement component 1, q subcomponent, B chain and complement component 1, q subcomponent, c chain) loci in relation to
Autor:
Timothy J. Vyse, Timothy W. Behrens, D S Cunninghame Graham, Patrick M. Gaffney, Kathy L. Moser, Robert R. Graham, David L. Morris, L. P. Erwig
Publikováno v:
Genes and Immunity
Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Genome-wide linkage studies implicated a region containing the adhesion molecule P-Selectin. This family-based study revealed two regions of association within P-Selectin. The strong
Autor:
Timothy J. Vyse, Thomas J. Hudson, Benjamin Rhodes, Joan E. Wither, S. Lim, CaNIOS GenES Investigators, Arlene H. Sharpe, Tamara McKenzie, Lauren Chad, John D. Rioux, Celia M. T. Greenwood, Alexandre Montpetit, L. Farwell, Y-C Cai, D S Cunninghame Graham, Cox Terhorst, Paul R. Fortin
Publikováno v:
Genes & Immunity. 9:93-102
Systemic lupus erythematosus (SLE) is a complex disease trait of unknown aetiology. Genome-wide linkage studies in human SLE identified several linkage regions, including one at 1q23, which contains multiple susceptibility genes, including the member
Publikováno v:
Human Molecular Genetics. 15:3195-3205
CD28, CTLA4 (cytotoxic T lymphocyte-associated protein 4) and ICOS (inducible T cell co-stimulator) are good candidate genes for systemic lupus erythematosus (SLE) because of their role in regulating T cell activation. CTLA4 inhibits CD28-mediated T
Autor:
CA Roberton, Sapna Chadha, D S Cunninghame Graham, David D'Cruz, Dorothea Nitsch, B Griffiths, Timothy J. Vyse, Andrew Russell, Tim J. Fernandez-Hart, John C. Whittaker
Publikováno v:
Genes & Immunity. 6:422-429
Altered function of selectin glycoprotein adhesion molecules may modulate severity and organ-specific manifestations of autoimmune and inflammatory disease via changes in leukocyte trafficking. Serum concentrations of selectin molecules have been sug
SUMMARYGenome wide linkage studies in human SLE have identified seven highly significant loci linked to SLE, and more than 20 other loci showing suggestive linkage to disease. However, pin-pointing the susceptibility alleles in candidate genes within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c017a0f7eba552e904d8fe06832defeb
https://europepmc.org/articles/PMC1809082/
https://europepmc.org/articles/PMC1809082/
Publikováno v:
Arthritis Research
The aetiology of systemic lupus erythematosus (SLE) is unknown. However, there is good evidence to support a genetic contribution in lupus, including a number of mouse strains that are genetically predisposed to develop lupus. Several groups have pub
Autor:
Rui, Xianliang, Alvarez Calderon, Francesca, Wobma, Holly, Gerdemann, Ulrike, Albanese, Alexandre, Cagnin, Lorenzo, McGuckin, Connor, Michaelis, Katherine A., Naqvi, Kisa, Blazar, Bruce R., Tkachev, Victor, Kean, Leslie S.
Publikováno v:
Science Translational Medicine; 10/16/2024, Vol. 16 Issue 769, p1-16, 16p
Autor:
Stockis, Julie, Yip, Thomas, Moreno-Vicente, Julia, Burton, Oliver, Samarakoon, Youhani, Schuijs, Martijn J., Raghunathan, Shwetha, Garcia, Celine, Luo, Weike, Whiteside, Sarah K., Png, Shaun, Simpson, Charlotte, Monk, Stela, Sawle, Ashley, Yin, Kelvin, Barbieri, Johanna, Papadopoulos, Panagiotis, Wong, Hannah, Rodewald, Hans-Reimer, Vyse, Timothy
Publikováno v:
Science Immunology; Jul2024, Vol. 9 Issue 97, p1-16, 16p
Autor:
Rae, William, Sowerby, John M., Verhoeven, Dorit, Youssef, Mariam, Kotagiri, Prasanti, Savinykh, Natalia, Coomber, Eve L., Boneparth, Alexis, Chan, Angela, Gong, Chun, Jansen, Machiel H., du Long, Romy, Santilli, Giorgia, Simeoni, Ilenia, Stephens, Jonathan, Wu, Kejia, Zinicola, Marta, Allen, Hana Lango, Baxendale, Helen, Kumararatne, Dinakantha
Publikováno v:
Science Immunology; 2022, Vol. 7 Issue 74, p1-15, 15p