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PREDICTION OF PLASMODIUM FALCIPARUM RESISTANCE TO SULFADOXINE/ PYRIMETHAMINE IN VIVO BY MUTATIONS IN THE DIHYDROFOLATE REDUCTASE AND DIHYDROPTEROATE SYNTHETASE GENES: A COMPARATIVE STUDY BETWEEN SITES OF DIFFERING ENDEMICITY

Autor: D. S. Tarimo, Richardo Thompson, Sonja Enosse, Anita M. Rønn, Martha M. Lemnge, Insaf F. Khalil, Ib C. Bygbjerg, Michael Alifrangis

Publikováno v: The American Journal of Tropical Medicine and Hygiene. 69:601-606

Plasmodium falciparum resistance to sulfadoxine/pyrimethamine (S/P) is due to mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhfr) genes. Large-scale screening of the prevalence of these mutations could facilitate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66207a2b8d298b7dae5aed40aababfd7
https://doi.org/10.4269/ajtmh.2003.69.601

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Perception of chloroquine efficacy and alternative treatments for uncomplicated malaria in children in a holoendemic area of Tanzania: implications for the change of treatment policy

Autor: D. S. Tarimo, J.N. Minjas, Ib C. Bygbjerg

Publikováno v: Tropical Medicine and International Health. 6:992-997

Prior to policy change from chloroquine (CQ) to sulphadoxine/pyrimethamine (S/P; Fansidar) we assessed the perception of CQ efficacy and the alternative treatment options for malaria in children among parents/guardians (N=527) of under-fives attendin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763fa46452e959851f1d7cc5c282acb9
https://doi.org/10.1046/j.1365-3156.2001.00818.x

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Mothers' perceptions and knowledge on childhood malaria in the holendemic Kibaha district, Tanzania: implications for malaria control and the IMCI strategy

Autor: Ib C. Bygbjerg, G. K. Lwihula, J.N. Minjas, D. S. Tarimo

Publikováno v: University of Copenhagen

Prior to an intervention on improving the quality of malaria case management the authors assessed mothers abilities to recognize nonsevere and severe/complicated malaria in children when a child has fever with other physiological and behavioral sympt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2726fea02719a1965d4bf7d9ab45086d
https://doi.org/10.1046/j.1365-3156.2000.00537.x

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Health workers perceptions on chloroquine and sulfadoxine/sulfalene pyrimethamine monotherapies: implications for the change to combination therapy of artemether/lumefantrine in Tanzania

Autor: D S, Tarimo, D A, Malekela

Publikováno v: East African journal of public health. 4(1)

To describe, from health workers (HWs) perspectives, the potential and actual barriers to the implementation of the first change of policy from chloroquine (CQ) to Sulfadoxine / Sulfalane - Pyrimewthamine (SP) in preparation for the second change of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee7874c88b2b757c85527ee4fb534297
https://pubmed.ncbi.nlm.nih.gov/17907761

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The roles of the pfcrt 76T and pfmdr1 86Y mutations, immunity and the initial level of parasitaemia, in predicting the outcome of chloroquine treatment in two areas with different transmission intensities

Autor: D. S. Tarimo, Michael Alifrangis, Gwiria M. H. Satti, Thor G. Theander, Trine Staalsø, Insaf F. Khalil, Anita M. Rønn, Ib C. Bygbjerg

Publikováno v: Annals of tropical medicine and parasitology. 99(5)

The resistance of Plasmodium falciparum to chloroquine (CQ) is probably mediated by point mutations in two genes: pfcrt and pfmdr1. The aim of the present study was to investigate, in patients treated with CQ, the association between host factors, su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3fa671174747725b846f302ee3c394d
https://pubmed.ncbi.nlm.nih.gov/16004703

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Sulfadoxine-pyrimethamine monotherapy in Tanzanian children gives rapid parasite clearance but slow fever clearance that is improved by chloroquine in combination therapy

Autor: J.N. Minjas, D. S. Tarimo, Ib C. Bygbjerg

Publikováno v: University of Copenhagen

Following widespread chloroquine (CQ) resistance sulfadoxine plus pyrimethamine (SP) is now the first line antimalarial drug in a number of African countries including Tanzania. Unlike CQ SP has no antipyretic effects a feature that might delay fever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e2b511a16be9a0b6b968ff6866d513
https://pubmed.ncbi.nlm.nih.gov/12100442

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Malaria diagnosis and treatment under the strategy of the integrated management of childhood illness (IMCI): relevance of laboratory support from the rapid immunochromatographic tests of ICT Malaria P.f/P.v and OptiMal

Autor: D S, Tarimo, J N, Minjas, I C, Bygbjerg

Publikováno v: Annals of tropical medicine and parasitology. 95(5)

The algorithm developed for the integrated management of childhood illness (IMCI) provides guidelines for the treatment of paediatric malaria. In areas where malaria is endemic, for example, the IMCI strategy may indicate that children who present wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::358997febf26e4310efdbc36facd1aeb
https://pubmed.ncbi.nlm.nih.gov/11487366

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Appraisal of the acridine orange method for rapid malaria diagnosis at three Tanzanian district hospitals

Autor: D S, Tarimo, R, Mpembeni, H, Kawawa, T C, Mshana

Publikováno v: East African medical journal. 75(9)

The need to have rapid and accurate confirmation of malaria parasitaemia prompted us to evaluate the direct Acridine Orange (AO) stain method in comparison to the traditional Giemsa Stain (GS) method in the detection of malaria parasites in patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa0765ee29feba520554f21fae6b5261
https://pubmed.ncbi.nlm.nih.gov/10493050

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Caretakers' perceptions of clinical manifestations of childhood malaria in holo-endemic rural communities in Tanzania

Autor: D S, Tarimo, D P, Urassa, G I, Msamanga

Publikováno v: East African medical journal. 75(2)

A cross-sectional household survey was carried out in Kibaha district, Tanzania to obtain caretakers' knowledge on symptoms of childhood malaria in children under five years of age in relation to its management. A total of 1530 caretakers were interv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2ecaae5830a7e25615c1bf17c46d232c
https://pubmed.ncbi.nlm.nih.gov/9640831

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