Phase I study of saracatinib (AZD0530) in combination with paclitaxel and/or carboplatin in patients with solid tumours

Autor: Jorge Barriuso, D. S. Tan, Epie Boven, D. Pietersma, Steinar Aamdal, E. G. E. de Vries, Shahneen Sandhu, Rita Ruijter, Gilles Freyer, Marta Nyakas, Sophie Barrett, M Stuart, Wendy Burke, Eric Pujade-Lauraine, Stan B. Kaye, U. Emeribe, Gunnar B. Kristensen, V. Hartog, Bart C. Kuenen, Robert Jones

Publikováno v: British Journal of Cancer
British Jounal of Cancer, 106(11), 1728-1734. Nature Publishing Group
Kaye, S, Aamdal, S, Jones, R, Freyer, G, Pujade-Lauraine, E, de Vries, E G E, Barriuso, J, Sandhu, S, Tan, D S W, Hartog, V, Kuenen, B, Ruijter, R, Kristensen, G B, Nyakas, M, Barrett, S, Burke, W, Pietersma, D, Stuart, M, Emeribe, U & Boven, E 2012, ' Phase I study of saracatinib (AZD0530) in combination with paclitaxel and/or carboplatin in patients with solid tumours ', British Journal of Cancer, vol. 106, no. 11, pp. 1728-1734 . https://doi.org/10.1038/bjc.2012.158
British Journal of Cancer, 106(11), 1728-1734. Nature Publishing Group

BACKGROUND: As a prelude to combination studies aimed at resistance reversal, this dose-escalation/dose-expansion study investigated the selective Src kinase inhibitor saracatinib (AZD0530) in combination with carboplatin and/or paclitaxel.METHODS: P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ececec11b616dbe3a4e3418b4c46e4da
https://doi.org/10.1038/bjc.2012.158

A new approach of forecasting intermittent demand for spare parts inventories in the process industries

Autor: D S Tan, Zheng-Shuang Hua, J Yang, Bin Zhang

Publikováno v: Journal of the Operational Research Society. 58:52-61

Accurate demand forecasting is of vital importance in inventory management of spare parts in process industries, while the intermittent nature makes demand forecasting for spare parts especially difficult. With the wide application of information tec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3f23815c7df39352c3f8459e5f9fb74
https://doi.org/10.1057/palgrave.jors.2602119

Ligand discovery using encoded combinatorial libraries

Autor: D S, Tan, J J, Burbaum

Publikováno v: Current opinion in drug discoverydevelopment. 3(4)

Solid-phase combinatorial synthesis using split-pool or direct divide methods allows large libraries of complex molecules to be generated. Encoding techniques used during synthesis allow the identities of the products to be determined readily. An ove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19e857a58537948f14229e856bbabc08
https://pubmed.ncbi.nlm.nih.gov/19649875

Cell cycle proteins do not predict outcome in grade I infiltrating ductal carcinoma of the breast

Autor: A C, Leong, A M, Hanby, H W, Potts, D S, Tan, D, Skilton, K, Ryder, W H, Harris, R D, Liebmann, D M, Barnes, C E, Gillett

Publikováno v: International journal of cancer. 89(1)

Infiltrating ductal mammary carcinomas are histologically graded according to their extent of differentiation. Well-differentiated, grade I, tumours have low proliferative activity, usually form tubules and exhibit little nuclear pleomorphism. Despit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::82102d458e7ef0a59e229415707cced8
https://pubmed.ncbi.nlm.nih.gov/10719727

The biological and prognostic significance of cell polarity and E-cadherin in grade I infiltrating ductal carcinoma of the breast

Autor: D S, Tan, H W, Potts, A C, Leong, C E, Gillett, D, Skilton, W H, Harris, R D, Liebmann, A M, Hanby

Publikováno v: The Journal of pathology. 189(1)

Grading of breast cancer based on the modified Scarff, Bloom, and Richardson system provides invaluable prognostic information. Recent evidence suggests that most tumours do not usually progress between grades and that groups of tumours within each g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::795a350dff2c25d06e9943c9268f3738
https://pubmed.ncbi.nlm.nih.gov/10451483