Zobrazeno 1 - 10
of 31
pro vyhledávání: '"D S, Shewach"'
Publikováno v:
JNCI Journal of the National Cancer Institute. 88:1193-1203
Chemotherapeutic drugs that perturb nucleotide metabolism have the potential to produce substantial sensitization of tumor cells to radiation treatment. The process is called radiosensitization, and the agents that induce it are called radiosensitize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51517adedab8b0250cbc3e809e7ae2a8
https://doi.org/10.1093/jnci/88.17.1193
https://doi.org/10.1093/jnci/88.17.1193
Autor:
B W, Robinson, D S, Shewach
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(8)
The nucleoside analogue 2',2'-difluoro-2'-deoxycytidine (dFdCyd) is a potent radiosensitizer in several solid tumor cell lines. Radiosensitization has correlated with the dFdCyd-mediated decrease in dATP levels and is S-phase specific. Previous studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6cf86b4f48cf7c5826f87bcaf94e5e63
https://pubmed.ncbi.nlm.nih.gov/11489842
https://pubmed.ncbi.nlm.nih.gov/11489842
Publikováno v:
Biochemistry. 40(4)
hsp90 and hsp70 are essential components of a five-protein system, including also the nonessential cochaperones Hop, hsp40, and p23, that assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f281ebdbb1e8e370821b6b9e9aad1e19
https://pubmed.ncbi.nlm.nih.gov/11170435
https://pubmed.ncbi.nlm.nih.gov/11170435
Publikováno v:
Oncology (Williston Park, N.Y.). 13(10 Suppl 5)
Gemcitabine is a potent radiosensitizer in both laboratory studies and in the clinic. Initial laboratory studies showed that gemcitabine radiosensitizes a wide variety of rodent and human tumor cells in culture. Maximum radiosensitization occurs in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31695b8ca2e81a325abea734aeb3ab6e
https://pubmed.ncbi.nlm.nih.gov/10550827
https://pubmed.ncbi.nlm.nih.gov/10550827
Autor:
W B, Parker, S C, Shaddix, L M, Rose, D S, Shewach, L W, Hertel, J A, Secrist, J A, Montgomery, L L, Bennett
Publikováno v:
Molecular pharmacology. 55(3)
In an effort to understand biochemical features that are important to the selective antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine [Cl-F( upward arrow)-dAdo], we evaluated the biochemical pharmacology of three stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b4d7445517df705c9b947bfadebfc66
https://pubmed.ncbi.nlm.nih.gov/10051535
https://pubmed.ncbi.nlm.nih.gov/10051535
Publikováno v:
Cancer research. 58(17)
Enzyme-prodrug therapy using ganciclovir and herpes simplex virus-thymidine kinase (HSV-TK) has demonstrated excellent antitumor activity in many different types of malignant cells. Previously, we noted that ganciclovir was substantially more cytotox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32118bdeefd523c0b5bd402d546cf683
https://pubmed.ncbi.nlm.nih.gov/9731497
https://pubmed.ncbi.nlm.nih.gov/9731497
Autor:
L L, Bennett, P W, Allan, G, Arnett, Y F, Shealy, D S, Shewach, W S, Mason, I, Fourel, W B, Parker
Publikováno v:
Antimicrobial agents and chemotherapy. 42(5)
The carbocyclic analog of 2′-deoxyguanosine (CdG) has broad-spectrum antiviral activity. Because of recent observations with other nucleoside analogs that biological activity may be associated the l enantiomer rather than, as expected, with the d e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c1d460c90ec98ab1dc74582ac64f241
https://pubmed.ncbi.nlm.nih.gov/9593124
https://pubmed.ncbi.nlm.nih.gov/9593124
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 3(5)
We have shown that 2',2'-difluoro-2'-deoxycytidine (dFdCyd; Gemcitabine), a deoxycytidine analogue, is a potent radiation sensitizer when cells are exposed to it continuously for16 h in low concentrations (in the range of 10 nM). However, the most co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f926093f4cd1f8738ee160c7cd6746a
https://pubmed.ncbi.nlm.nih.gov/9815749
https://pubmed.ncbi.nlm.nih.gov/9815749
Publikováno v:
Seminars in oncology. 24(2 Suppl 7)
Gemcitabine is a potent radiosensitizer of human tumor cells. This review summarizes our preclinical and early clinical studies designed to elucidate the mechanism of action of gemcitabine and phase I trials conducted to determine the optimal dose an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::34973e702caedfbe645ea843acc73c17
https://pubmed.ncbi.nlm.nih.gov/9194476
https://pubmed.ncbi.nlm.nih.gov/9194476
Autor:
D S, Shewach, T S, Lawrence
Publikováno v:
Seminars in oncology. 23(5 Suppl 10)
Gemcitabine has high clinical activity in several solid tumors that are treated with radiotherapy and/or chemotherapy. The mode of action of gemcitabine involves a number of intracellular changes that are shared by other radiation sensitizing antican
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6dc80475d76d38b263f950559b978157
https://pubmed.ncbi.nlm.nih.gov/8893885
https://pubmed.ncbi.nlm.nih.gov/8893885