Zobrazeno 1 - 10
of 93
pro vyhledávání: '"D S, Pisetsky"'
Autor:
D S, Pisetsky
Publikováno v:
Advances in protein chemistry and structural biology. 106
Chromatin is a highly conserved molecular structure that provides genetic information to regulate cell function. Comprised of DNA, histones and interacting proteins, chromatin is inherently dynamic and subject to remodeling. While usually conceptuali
Publikováno v:
Apoptosis. 10:731-741
Microparticles are small membrane vesicles released from the cell membrane by exogenous budding. To elucidate the interactions of microparticles with macrophages, the effect of microparticles released from Jurkat T cells on RAW 264.7 cells was determ
Autor:
D S, Pisetsky
Publikováno v:
Springer Seminars in Immunopathology. 22:153-166
Publikováno v:
The Journal of Immunology. 158:4500-4506
To elucidate the mechanism of Ag drive in the anti-DNA response, the Ab response to bacterial DNA has been analyzed in normal and autoimmune mice. Preautoimmune NZB/W mice immunized with Escherichia coli dsDNA produce Abs that resemble spontaneous au
Publikováno v:
The Journal of Immunology. 157:4371-4378
CD19 serves as a cell surface response regulator that establishes signaling thresholds critical for B lymphocyte development and activation. B lymphocytes from CD19-deficient mice are hyporesponsive to transmembrane signals, while B lymphocytes from
Autor:
D S, Pisetsky
Publikováno v:
Scandinavian journal of immunology. 76(3)
Antinuclear antibodies (ANAs) are a diverse group of autoantibodies that bind macromolecular components of the cell nucleus. While some ANAs occur in normal individuals, others are expressed almost exclusively in patients with rheumatic disease and s
Publikováno v:
The Journal of Immunology. 153:5104-5120
Rheumatoid factors (RF) and anti-DNA Abs from MRL/lpr mice have features similar to Abs directed toward foreign Ags, indicating a role of specific activation by Ags during disease. But our previous studies and analogous studies from others concentrat
Autor:
C F, Reich, D S, Pisetsky
Publikováno v:
Methods in molecular medicine. 29
DNA vaccination represents a powerful new approach for the elicitation of long-lived protective immunity against a broad range of protein antigens (1,2). In this approach, the vaccine is a plasmid DNA vector that encodes a foreign protein to be targe
Publikováno v:
The Journal of Immunology. 151:1353-1364
Immunization of normal mice with bacterial DNA induces a significant anti-DNA response that includes antibodies resembling some lupus anti-DNA in their binding properties, although lacking specificity for mammalian dsDNA. To determine the structure o
Publikováno v:
The Journal of Immunology. 147:1759-1764
Although DNA is generally considered to be a poor immunogen, recent evidence suggests that DNA from various species differ in their immunologic activity and that bacterial DNA, unlike mammalian DNA, can induce significant antibody responses in mice.